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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="other" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Terapevticheskii arkhiv</journal-id><journal-title-group><journal-title xml:lang="en">Terapevticheskii arkhiv</journal-title><trans-title-group xml:lang="ru"><trans-title>Терапевтический архив</trans-title></trans-title-group></journal-title-group><issn publication-format="print">0040-3660</issn><issn publication-format="electronic">2309-5342</issn><publisher><publisher-name xml:lang="en">LLC Obyedinennaya Redaktsiya</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">30838</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Editorial article</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Передовая статья</subject></subj-group><subj-group subj-group-type="article-type"><subject></subject></subj-group></article-categories><title-group><article-title xml:lang="en">Standardization of methotrexate administration in routine rheumatological practice</article-title><trans-title-group xml:lang="ru"><trans-title>Вопросы стандартизации применения метотрексата в ежедневной практике ревматолога</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Murav'ev</surname><given-names>Yuriy Vladimirovich</given-names></name><name xml:lang="ru"><surname>Муравьев</surname><given-names>Юрий Владимирович</given-names></name></name-alternatives><bio xml:lang="ru"><p>д-р мед. наук, проф., зав. лаб. по изучению безопасности антиревматических препаратов, тел.: 8-499-614-42-82; Научно-исследовательский институт ревматологии РАМН</p></bio><email>murawyu@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name><surname>Muravyev</surname><given-names>Yu V</given-names></name><bio xml:lang="en"><p>Research Institute of Rheumatology of the Russian Academy of Medical Sciences, Moscow</p></bio><xref ref-type="aff" rid="aff2"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en"></institution></aff><aff><institution xml:lang="ru">Научно-исследовательский институт ревматологии РАМН</institution></aff></aff-alternatives><aff-alternatives id="aff2"><aff><institution xml:lang="en">Research Institute of Rheumatology of the Russian Academy of Medical Sciences, Moscow</institution></aff><aff><institution xml:lang="ru"></institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2011-05-15" publication-format="electronic"><day>15</day><month>05</month><year>2011</year></pub-date><volume>83</volume><issue>5</issue><issue-title xml:lang="en">NO5 (2011)</issue-title><issue-title xml:lang="ru">ТОМ 83, №5 (2011)</issue-title><fpage>33</fpage><lpage>37</lpage><history><date date-type="received" iso-8601-date="2020-04-10"><day>10</day><month>04</month><year>2020</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2011, Consilium Medicum</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2011, ООО "Консилиум Медикум"</copyright-statement><copyright-year>2011</copyright-year><copyright-holder xml:lang="en">Consilium Medicum</copyright-holder><copyright-holder xml:lang="ru">ООО "Консилиум Медикум"</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://creativecommons.org/licenses/by-nc-sa/4.0</ali:license_ref></license></permissions><self-uri xlink:href="https://ter-arkhiv.ru/0040-3660/article/view/30838">https://ter-arkhiv.ru/0040-3660/article/view/30838</self-uri><abstract xml:lang="en"><p>The review is devoted to administration of methotrexate - a basic anti-inflammatory drug - in rheumatoid arthritis. Some issues of practical use of this drug are still disputable. Recommendations of international experts and information on standardization for patients are considered.</p></abstract><trans-abstract xml:lang="ru"><p>Обзор посвящен вопросам практического назначения метотрексата - ключевого базисного противовоспалительного препарата - при ревматоидном артрите, по которым среди ревматологов до настоящего времени не достигнуто согласованное мнение. Рассматриваются рекомендации международных экспертов и данные о стандартизации информации для больных.</p></trans-abstract><kwd-group xml:lang="en"><kwd>methotraxate</kwd><kwd>rheumatoid arthritis</kwd><kwd>basic anti-inflammatory drug</kwd><kwd>every-day practice</kwd><kwd>standardization</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>метотрексат</kwd><kwd>ревматоидный артрит</kwd><kwd>базисный противовоспалительный препарат</kwd><kwd>ежедневная практика</kwd><kwd>стандартизация</kwd></kwd-group></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Gubner R. S., August V. R. Therapeutic suppression of tussue reactivity to effective aminopterin in rheumatoid arthritis and psoriasis. Am. J. Med. Sci. 1950; 220: 176-183.</mixed-citation></ref><ref id="B2"><label>2.</label><mixed-citation>Weinblatt M. E., Coblyn J. S., Fox D. A. et al. Efficacy of low-dose methotrexate in rheumatoid arthritis. N. Engl. J. 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