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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="other" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Terapevticheskii arkhiv</journal-id><journal-title-group><journal-title xml:lang="en">Terapevticheskii arkhiv</journal-title><trans-title-group xml:lang="ru"><trans-title>Терапевтический архив</trans-title></trans-title-group></journal-title-group><issn publication-format="print">0040-3660</issn><issn publication-format="electronic">2309-5342</issn><publisher><publisher-name xml:lang="en">LLC Obyedinennaya Redaktsiya</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">30764</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Editorial article</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Передовая статья</subject></subj-group><subj-group subj-group-type="article-type"><subject></subject></subj-group></article-categories><title-group><article-title xml:lang="en">Baroreflex sensitivity in patients with chronic heart failure: the clinical significance and impact of therapy</article-title><trans-title-group xml:lang="ru"><trans-title>ЧУВСТВИТЕЛЬНОСТЬ БАРОРЕФЛЕКСА У БОЛЬНЫХ С ХРОНИЧЕСКОЙ СЕРДЕЧНОЙ НЕДОСТАТОЧНОСТЬЮ: КЛИНИЧЕСКОЕ ЗНАЧЕНИЕ И ВЛИЯНИЕ ТЕРАПИИ</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Nepoklonov</surname><given-names>Mikhail Viktorovich</given-names></name><name xml:lang="ru"><surname>Непоклонов</surname><given-names>Михаил Викторович</given-names></name></name-alternatives><bio xml:lang="ru"><p>аспирант, отд. заболеваний миокарда и сердечной недостаточности, Институт клинической кардиологии им. А. Л. Мясникова, ФГУ РКНПК Росмедтехнологий, тел.: 8-495-414-61-46; ФГУ Российский кардиологический научно-производственный комплекс Росмедтехнологий</p></bio><email>lesstalkmorerock@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Rogoza</surname><given-names>Anatoliy Nikolaevich</given-names></name><name xml:lang="ru"><surname>Рогоза</surname><given-names>Анатолий Николаевич</given-names></name></name-alternatives><bio xml:lang="ru"><p>д-р биол. наук, проф., рук. отд. новых методов диагностики, Институт клинической кардиологии им. А. Л. Мясникова, ФГУ РКНПК Росмедтехнологий, тел.: 8-495-414-63-58; ФГУ Российский кардиологический научно-производственный комплекс Росмедтехнологий</p></bio><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Skvortsov</surname><given-names>Andrey Aleksandrovich</given-names></name><name xml:lang="ru"><surname>Скворцов</surname><given-names>Андрей Александрович</given-names></name></name-alternatives><bio xml:lang="ru"><p>д-р мед. наук, вед. науч. сотр., отд. заболеваний миокарда и сердечной недостаточности, Институт клинической кардиологии им. А. Л. Мясникова, ФГУ РКНПК Росмедтехнологий, тел.: 8-495-414-60-41; ФГУ Российский кардиологический научно-производственный комплекс Росмедтехнологий</p></bio><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Gorieva</surname><given-names>Shurat Bodzievna</given-names></name><name xml:lang="ru"><surname>Гориева</surname><given-names>Шурат Бодзиевна</given-names></name></name-alternatives><bio xml:lang="ru"><p>канд. мед. наук, науч. сотр., отд. новых методов диагностики, Институт клинической кардиологии им. А. Л. Мясникова, ФГУ РКНПК Росмедтехнологий, тел.: 8-495-414-65-29; ФГУ Российский кардиологический научно-производственный комплекс Росмедтехнологий</p></bio><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Tereshchenko</surname><given-names>Sergey Nikolaevich</given-names></name><name xml:lang="ru"><surname>Терещенко</surname><given-names>Сергей Николаевич</given-names></name></name-alternatives><bio xml:lang="ru"><p>д-р мед. наук, проф., рук. отд. заболеваний миокарда и сердечной недостаточности, Институт клинической кардиологии им. А. Л. Мясникова, ФГУ РКНПК Росмедтехнологий, тел.: 8-495-414-61-17; ФГУ Российский кардиологический научно-производственный комплекс Росмедтехнологий</p></bio><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name><surname>Nepoklonov</surname><given-names>M V</given-names></name><bio xml:lang="en"><p>Russian Cardiology Research-and-Production Complex, Russian Agency for Medical Technologies</p></bio><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><name><surname>Rogoza</surname><given-names>A N</given-names></name><bio xml:lang="en"><p>Russian Cardiology Research-and-Production Complex, Russian Agency for Medical Technologies</p></bio><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><name><surname>Skvortsov</surname><given-names>A A</given-names></name><bio xml:lang="en"><p>Russian Cardiology Research-and-Production Complex, Russian Agency for Medical Technologies</p></bio><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><name><surname>Goriyeva</surname><given-names>Sh B</given-names></name><bio xml:lang="en"><p>Russian Cardiology Research-and-Production Complex, Russian Agency for Medical Technologies</p></bio><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><name><surname>Tereshchenko</surname><given-names>S N</given-names></name><bio xml:lang="en"><p>Russian Cardiology Research-and-Production Complex, Russian Agency for Medical Technologies</p></bio><xref ref-type="aff" rid="aff2"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en"></institution></aff><aff><institution xml:lang="ru">ФГУ Российский кардиологический научно-производственный комплекс Росмедтехнологий</institution></aff></aff-alternatives><aff-alternatives id="aff2"><aff><institution xml:lang="en">Russian Cardiology Research-and-Production Complex, Russian Agency for Medical Technologies</institution></aff><aff><institution xml:lang="ru"></institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2010-12-15" publication-format="electronic"><day>15</day><month>12</month><year>2010</year></pub-date><volume>82</volume><issue>12</issue><issue-title xml:lang="en">NO12 (2010)</issue-title><issue-title xml:lang="ru">ТОМ 82, №12 (2010)</issue-title><fpage>73</fpage><lpage>80</lpage><history><date date-type="received" iso-8601-date="2020-04-09"><day>09</day><month>04</month><year>2020</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2010, Consilium Medicum</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2010, ООО "Консилиум Медикум"</copyright-statement><copyright-year>2010</copyright-year><copyright-holder xml:lang="en">Consilium Medicum</copyright-holder><copyright-holder xml:lang="ru">ООО "Консилиум Медикум"</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://creativecommons.org/licenses/by-nc-sa/4.0</ali:license_ref></license></permissions><self-uri xlink:href="https://ter-arkhiv.ru/0040-3660/article/view/30764">https://ter-arkhiv.ru/0040-3660/article/view/30764</self-uri><abstract xml:lang="en"><p>The review deals with the baroreflex regulation of circulation in chronic heart failure (CHF). The pathophysiological aspects of development of dysfunction of the baroreflex clinically estimated from its sensitivity are presented; the clinical value of this indicator is discussed in relation to the etiology of the underlying disease and clinicohemodynamic status. Data on the impact of some components of current therapy for CHF and nondrug treatments on the values of baroreflex sensitivity are shown.</p></abstract><trans-abstract xml:lang="ru"><p>Обзор посвящен состоянию барорефлекторной регуляции кровообращения при хронической сердечной недостаточности (ХСН). Представлены патофизиологические аспекты формирования барорефлекторной дисфункции, клинически оцениваемой по чувствительности барорефлекса, обсуждается клиническое значение этого показателя в зависимости от этиологии основного заболевания и клинико-гемодинамического статуса. Отражены данные о влиянии на показатели чувствительности барорефлекса отдельных компонентов современной терапии ХСН и немедикаментозных методов лечения.</p></trans-abstract><kwd-group xml:lang="en"><kwd>baroreflex sensitivity</kwd><kwd>chronic heart failure</kwd><kwd>clinical significance</kwd><kwd>impact of therapy</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>чувствительность барорефлекса</kwd><kwd>хроническая сердечная недостаточность</kwd><kwd>клиническое значение</kwd><kwd>влияние терапии</kwd></kwd-group></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Eckberg D. L., Sleight P. Human baroreflexes in health and disease. Oxford: Clarendon Press; 1992.</mixed-citation></ref><ref id="B2"><label>2.</label><mixed-citation>Grassi G., Seravalle G., Cattaneo B. M. et al. Sympathetic activation and loss of reflex sympathetic control in mild congestive heart failure. Circulation 1995; 92: 3206-3211.</mixed-citation></ref><ref id="B3"><label>3.</label><mixed-citation>Fergusson D. W., Berg W. J., Sanders J. S. Clinical and hemodynamic correlates of sympathetic nerve activity in normal humans and patients with heart failure: evidence from direct microneurographic recordings. J. Am. Coll. Cardiol. 1990; 16: 1125-1134.</mixed-citation></ref><ref id="B4"><label>4.</label><mixed-citation>Guzzetti S., Cogliati C., Turiel M. et al. Sympathetic predominance in the progression of chronic heart failure. Eur. Heart J. 1995; 16: 1100-1107.</mixed-citation></ref><ref id="B5"><label>5.</label><mixed-citation>Eaton G. M., Cody R. J., Nunziata E., Binkley P. F. Early left ventricular dysfunction elicits activation of sympathetic drive and attenuation of parasympathetic tone in the paced model of congestive heart failure. Circulation 1995; 92: 555-561.</mixed-citation></ref><ref id="B6"><label>6.</label><mixed-citation>Kinugawa T., Dibner-Dunlap M. E. Altered vagal and sympathetic control of heart rate in left ventricular dysfunction and heart failure. Am. J. Physiol. 1995; 268: R317-R323.</mixed-citation></ref><ref id="B7"><label>7.</label><mixed-citation>Portar T. R., Eckberg D. L., Fritsch J. M. et al. Autonomic pathophysiology in heart failure patients. J. Clin. Invest. 1990; 85: 1362-1371.</mixed-citation></ref><ref id="B8"><label>8.</label><mixed-citation>Wang W. Chronic administration of aldosterone depresses baroreceptor reflex function in the dog. Hypertension 1994; 24: 571-575.</mixed-citation></ref><ref id="B9"><label>9.</label><mixed-citation>Monahan K. D., Urs A. et al. Aldosterone impairs baroreflex sensitivity in healthy adults. Am. J. Physiol. Heart Circ. Physiol. 2007; 292: H190-H197.</mixed-citation></ref><ref id="B10"><label>10.</label><mixed-citation>Wang W., Jwo-Sheng C., Zucker I. H. Carotid sinus baroreceptor sensitivity in experimental heart failure. Circulation 1990; 81: 1959-1966.</mixed-citation></ref><ref id="B11"><label>11.</label><mixed-citation>Monahan K. D., Tanaka H., Dinenno F. A. et al. Central arterial compliance is associated with age- and habitual exercise-related differences in cardiovagal baroreflex sensitivity. Circulation 2001; 104: 1627-1632.</mixed-citation></ref><ref id="B12"><label>12.</label><mixed-citation>Francis G. S., Benedict C., Johnstone D. E. et al. Comparison of neuroendocrine activation in patients with left ventricular dysfunction with and without congestive heart failure: a substudy of the Studies of Left Ventricular Dysfunction (SOLVD). Circulation 1990; 82: 1724-1729.</mixed-citation></ref><ref id="B13"><label>13.</label><mixed-citation>Packer M. The neurohormonal hypothesis: a theory to explain the mechanism of disease progression in heart failure. J. Am. Coll. Cardiol. 1992; 20: 248-254.</mixed-citation></ref><ref id="B14"><label>14.</label><mixed-citation>Floras J. S. Clinical aspects of sympathetic activation and parasympathetic withdrawal in heart failure. J. Am. Coll. Cardiol. 1993; 22(Suppl. A): 72A-84A.</mixed-citation></ref><ref id="B15"><label>15.</label><mixed-citation>Cohn J. N., Levine T. B., Olivari M. T. et al. Plasma norepinephrine as a guide to prognosis in patients with chronic congestive heart failure. N. Engl. J. Med. 1984; 311: 819-823.</mixed-citation></ref><ref id="B16"><label>16.</label><mixed-citation>Mancia G., Seravalle G., Giannattasio C. et al. Reflex cardiovascular control in congestive heart failure. Am. J. Cardiol. 1992; 69: 17G-23G.</mixed-citation></ref><ref id="B17"><label>17.</label><mixed-citation>Schwartz P. J., Billman G. E., Stone H. L. Autonomic mechanisms in ventricular fibrillation induced by myocardial ischemia during exercise in dogs with a healed myocardial infarction. Circulation 1984; 69: 780-790.</mixed-citation></ref><ref id="B18"><label>18.</label><mixed-citation>Mortara A., La Rovere M. T., Pinna G. D. et al. Arterial baroreflex modulation of heart rate in chronic heart failure: clinical and hemodynamic correlates and prognostic implications. Circulation 1997; 96: 3450-3458.</mixed-citation></ref><ref id="B19"><label>19.</label><mixed-citation>Marin-Neto J. A., Pintya A. O., Gallo Jьnior L., Maciel B. C. Abnormal baroreflex control of heart rate in decompensated congestive heart failure and reversal after compensation. Am. J. Cardiol. 1991; 67(7): 604.</mixed-citation></ref><ref id="B20"><label>20.</label><mixed-citation>La Rovere M. T., Bigger J. T. Jr., Marcus F. I. et al. for the ATRAMI (Autonomic Tone and Reflexes After Myocardial Infarction) Investigators. Baroreflex sensitivity and heart rate variability in prediction of total cardiac mortality after myocardial infarction. Lancet 1998; 351: 478-484.</mixed-citation></ref><ref id="B21"><label>21.</label><mixed-citation>De Ferrari G. M., Sanzo A., Bertoletti A. et al. Baroreflex sensitivity predicts longterm cardiovascular mortality after myocardial infarction even in patients with preserved left ventricular function. J. Am. Coll. Cardiol. 2007; 50(24): 2285-2290.</mixed-citation></ref><ref id="B22"><label>22.</label><mixed-citation>Grimm W., Glaveris C., Hoffmann J. et al. Noninvasive risk stratification in idiopathic dilated cardiomyopathy: and first results of the Marburg Cardiomyopathy Study. Pace 1998; 21(II): 2551-2556.</mixed-citation></ref><ref id="B23"><label>23.</label><mixed-citation>Grassi G., Seravalle G., Quarti-Trevano F., Dell'Oro R. Left ventricular dysfunction sympathetic and baroreflex cardiovascular control in hypertension-related left ventricular dysfunction. Hypertension 2009; 53: 205-209.</mixed-citation></ref><ref id="B24"><label>24.</label><mixed-citation>Grassi G., Cattaneo B. M., Seravalle G. et al. Baroreflex control of sympathetic nerve activity in essential and secondary hypertension. Hypertension 1998; 31: 68-72.</mixed-citation></ref><ref id="B25"><label>25.</label><mixed-citation>Grassi G., Bolla G. B., Seravalle G. et al. Comparison between reproducibility and sensitivity of muscle sympathetic nerve traffic and plasma noradrenaline in man. Clin. Sci. 1997; 92: 285-289.</mixed-citation></ref><ref id="B26"><label>26.</label><mixed-citation>Milan A., Caserta M. A., Del Colle S. et al. Baroreflex sensitivity correlates with left ventricular morphology and diastolic function in essential hypertension. J. Hypertension 2007; 25(8): 1655-1664.</mixed-citation></ref><ref id="B27"><label>27.</label><mixed-citation>Schillaci G., Pasqualini L., Verdecchia P. et al. Prognostic significance of left ventricular diastolic dysfunction in essential hypertension. J. Am. Coll. Cardiol. 2002; 39: 2005-2011.</mixed-citation></ref><ref id="B28"><label>28.</label><mixed-citation>Grassi G. Role of the sympathetic nervous system in human hypertension. J. Hypertens. 1998; 16: 1979-1987.</mixed-citation></ref><ref id="B29"><label>29.</label><mixed-citation>Eleuteri E., Lanfranchi P., Scapellato F. et al. Restrictive left ventricular filling pattern as a strong predictor of depressed baroreflex sensitivity in heart failure. Ital. Heart J. 2001; 2(5): 344-348.</mixed-citation></ref><ref id="B30"><label>30.</label><mixed-citation>Likoff M. J., Chandler S. L., Kay H. R. Clinical determinants of mortality in chronic congestive heart failure secondary to idiopathic dilated or to ischemic cardiomyopathy. Am. J. Cardiol. 1987; 59: 634-638.</mixed-citation></ref><ref id="B31"><label>31.</label><mixed-citation>La Rovere M. T., Specchia G., Mortara A., Schwartz P. J. Baroreflex sensitivity, clinical correlates, and cardiovascular mortality among patients with a first myocardial infarction. A prospective study. Circulation 1988; 78: 816-824.</mixed-citation></ref><ref id="B32"><label>32.</label><mixed-citation>Rovere M. T., Mortara A., Specchia G., Schwartz P. J. Myocardial infarction and baroreflex sensitivity. Clinical studies. G. Ital. Cardiol. 1992; 22: 639-645.</mixed-citation></ref><ref id="B33"><label>33.</label><mixed-citation>Osterziel K. J., Hanlein D., Willenbrock R. et al. Baroreflex sensitivity and cardiovascular mortality in patients with mild to moderate heart failure. Br. Heart J. 1995; 73: 517.</mixed-citation></ref><ref id="B34"><label>34.</label><mixed-citation>Moss A. J., Hall W. J., Cannom D. S. et al. Multicenter Automatic Defibrillator Implantation Trial Investigators. Improved survival with an implanted defibrillator in patients with coronary disease at high risk for ventricular arrhythmia. N. Engl. J. Med. 1996; 335: 1933-1940.</mixed-citation></ref><ref id="B35"><label>35.</label><mixed-citation>Buxton A. E., Lee K. L., Di Carlo L. et al. Multicenter Unsustained Tachycardia Trial Investigators. Electrophysiologic testing to identify patients with coronary artery disease who are at risk for sudden death. N. Engl. J. Med. 2000; 342: 1937-1945.</mixed-citation></ref><ref id="B36"><label>36.</label><mixed-citation>Moss A. J., Zareba W., Hall W. J. et al. Multicenter Automatic Defibrillator Implantation Trial II Investigators. Prophylactic implantation of a defibrillator in patients with myocardial infarction and reduced ejection fraction. N. Engl. J. Med. 2002; 346: 877-883.</mixed-citation></ref><ref id="B37"><label>37.</label><mixed-citation>Bardy G. H., Lee K. L., Mark D. B. et al. Sudden Cardiac Death in Heart Failure Trial (SCD-HeFT) Investigators. Amiodarone or an implantable cardioverter-defibrillator for congestive heart failure. N. Engl. J. Med. 2005; 352: 225-237.</mixed-citation></ref><ref id="B38"><label>38.</label><mixed-citation>Buxton A. E. Should everyone with an ejection fraction less than or equal to 30% receive an implantable cardioverter-defibrillator? Not everyone with an ejection fraction &lt; or = 30% should receive an implantable cardioverter-defibrillator. Circulation 2005; 111: 2537-2549.</mixed-citation></ref><ref id="B39"><label>39.</label><mixed-citation>Anderson K. P., Freedman R. A., Maron J. W. Sudden death in idiopathic dilated cardiomyopathy. Ann. Intern. Med. 1987; 107: 104-106.</mixed-citation></ref><ref id="B40"><label>40.</label><mixed-citation>Bigger J. T. Why patients with congestive heart failure die. Arrhythmias and sudden cardiac death. Circulation 1987; 75(Suppl. IV): IV-28-IV-35.</mixed-citation></ref><ref id="B41"><label>41.</label><mixed-citation>Schwartz P. J., La Rovere M. T., Vanoli E. Autonomic nervous system and sudden cardiac death. Experimental basis and clinical observations for post-myocardial infarction risk stratification. Circulation 1992; 85(Suppl. I): I-77-I-91.</mixed-citation></ref><ref id="B42"><label>42.</label><mixed-citation>La Rovere M. T., Pinna G. D., Hohnloser S. H. et al. Baroreflex sensitivity and heart rate variability in the identification of patients at risk for life-threatening arrhythmias: implications for clinical trials. Circulation 2001; 103: 2072-2077.</mixed-citation></ref><ref id="B43"><label>43.</label><mixed-citation>Ishise H., Asanoi H., Ishizaka S. et al. Time course of sympathovagal imbalance and left ventricular dysfunction in conscious dogs with heart failure. J. Appl. Physiol. 1998; 84: 1234-1241.</mixed-citation></ref><ref id="B44"><label>44.</label><mixed-citation>Binkley P. F., Haas G. S., Starling R. C. et al. Sustained augmentation of parasympathetic tone with angiotensin-converting enzyme inhibition in patients with congestive heart failure. J. Am. Coll. Cardiol. 1993; 21: 655-661.</mixed-citation></ref><ref id="B45"><label>45.</label><mixed-citation>Kamen P. W., Krum H., Tonkin A. M. Low dose but not high dose captopril increases parasympathetic activity in patients with heart failure. J. Cardiovasc. Pharmacol. 1997; 30: 7-11.</mixed-citation></ref><ref id="B46"><label>46.</label><mixed-citation>Osterziel K. J., Dietz R. Improvement of vagal tone by ACE inhibitors: a mechanism of cardioprotection in patients with mild to moderate heart failure. J. Cardiovasc. Pharmacol. 1996; 27: S25-S30.</mixed-citation></ref><ref id="B47"><label>47.</label><mixed-citation>Grassi G., Cattaneo B. M., Seravalle G. et al. Effects of chronic ACE inhibition on sympathetic nerve traffic and baroreflex control of circulation in heart failure. Circulation 1997; 96: 1173-1179.</mixed-citation></ref><ref id="B48"><label>48.</label><mixed-citation>Dibner-Dunlap M. E., Smith M. L., Kinugawa T., Thames M. D. Enalaprilat augments arterial and cardiopulmonary baroreflex control of sympathetic nerve activity in patients with heart failure. J. Am. Coll. Cardiol. 1996; 27: 358-364.</mixed-citation></ref><ref id="B49"><label>49.</label><mixed-citation>Lewis G. P., Reit E. The action of angiotensin and bradykinin on the superior cervical ganglion of the cat. J. Physiol. (Lond.) 1965; 179: 538-553.</mixed-citation></ref><ref id="B50"><label>50.</label><mixed-citation>Shimamoto K., Matsuki T., Iimura O. Angiotensin converting enzyme inhibitors and the kallikrein-kinin system. J. Cardiovasc. Pharmacol. 1995; 15(Suppl. 6): S91-S98.</mixed-citation></ref><ref id="B51"><label>51.</label><mixed-citation>Grassi G., Giannattasio C., Failla M. et al. Sympathetic modulation of radial artery compliance in congestive heart failure. Hypertension 1995; 26: 348-354.</mixed-citation></ref><ref id="B52"><label>52.</label><mixed-citation>Binkley P. F., Nunziata E., Haas G. J. et al. Dissociation between ACE activity and autonomic response to ACE inhibition in patients with heart failure. Am. Heart J. 2000; 140(1): 34-42.</mixed-citation></ref><ref id="B53"><label>53.</label><mixed-citation>Guo G. B., Abboud F. M. Angiotensin II attenuates baroreflex control of heart rate and sympathetic activity. Am. J. Physiol. 1984; 246: H80-H89.</mixed-citation></ref><ref id="B54"><label>54.</label><mixed-citation>Mancia G., Mark A. L. Arterial baroreflex in humans. In: Shepherd J. T., Abboud F. M., eds. Handbook of physiology. Sect. 2: The cardiovascular system. Bethesda, Md: American Physiological Society; 1983. 755-793.</mixed-citation></ref><ref id="B55"><label>55.</label><mixed-citation>Pickering T. G., Gribbin B., Petersen E. S. et al. Effects of autonomic blockade on the baroreflexes in man at rest and during exercise. Circ. Res. 1972; 30: 175-185.</mixed-citation></ref><ref id="B56"><label>56.</label><mixed-citation>Eckberg D. L., Abboud F. M., Mark A. L. Modulation of carotid baroreflex responsiveness in man: effects of posture and propanolol. J. Appl. Physiol. 1976; 41: 383-3787.</mixed-citation></ref><ref id="B57"><label>57.</label><mixed-citation>Pitzalis M. V., Mastropasqua F., Massari F. et al. Beta-blocker effects on respiratory sinus arrhythmia and baroreflex gain in normal subjects. Chest 1998; 114: 185-191.</mixed-citation></ref><ref id="B58"><label>58.</label><mixed-citation>Floras J. S., Jones J. V., Hassan M. O., Sleight P. Effects of acute and chronic beta-adrenoceptor blockade on baroreflex sensitivity in humans. J. Auton. Nerv. Syst. 1988; 25: 87-94.</mixed-citation></ref><ref id="B59"><label>59.</label><mixed-citation>Parati G., Mutti E., Frattola A. et al. Beta-adrenergic blocking treatmant and 24-h baroreflex sensitivity in essential hypertensive patients. Hypertension 1994; 23: 992-996.</mixed-citation></ref><ref id="B60"><label>60.</label><mixed-citation>Lechat P., Packer M., Chalon S. et al. Clinical effects of beta-adrenergic blockade in chronic heart failure. A meta-analysis of double blind, placebo-controlled, randomized trials. Circulation 1998; 98: 1184-1191.</mixed-citation></ref><ref id="B61"><label>61.</label><mixed-citation>Frishman W. H. Carvedilol. N. Engl. J. Med. 1998; 339: 1759-1765.</mixed-citation></ref><ref id="B62"><label>62.</label><mixed-citation>Kubo T., Parker J. D., Azevedo E. R. et al. Vagal heart rate responses to chronic beta-blockade in human heart failure relate to cardiac norepinephrine spillover. Eur. J. Heart Fail. 2005; 7: 878-881.</mixed-citation></ref><ref id="B63"><label>63.</label><mixed-citation>Xu X. L., Zang W. J., Lu J. et al. Effects of carvedilol on M2 receptors and cholinesterase-positive nerves in adriamycininduced rat failing heart. Auton. Neurosci. 2006; 130: 6-16.</mixed-citation></ref><ref id="B64"><label>64.</label><mixed-citation>Keeley E. C., Page R. L., Lange R. A. et al. Influence of metoprolol on heart rate variability in survivors of remote myocardial infarction. Am. J. Cardiol. 1996; 77: 557-560.</mixed-citation></ref><ref id="B65"><label>65.</label><mixed-citation>Sanderson J. E., Yeung L. Y., Chan S. et al. Effect of beta-blockade on baroreceptor and autonomic function in heart failure. Clin. Sci. 1999; 96: 137-146.</mixed-citation></ref><ref id="B66"><label>66.</label><mixed-citation>Mortara A., La Rovere M. T. Nonselective beta-adrenergic blocking agent, carvedilol, improves arterial baroflex gain and heart rate variability in patients with stable chronic heart failure. J. Am. Coll. Cardiol. 2000; 36: 1612-1618.</mixed-citation></ref><ref id="B67"><label>67.</label><mixed-citation>Vaile J. C., Chowdhary S., Osman F. et al. Effects of angiotensin II (ATII) receptor blockade on cardiac vagal control in heart failure. Clin. Sci. 2001; 101(6): 559-566.</mixed-citation></ref><ref id="B68"><label>68.</label><mixed-citation>Hikosaka M., Yuasa F., Yuyama R. et al. Candesartan and arterial baroreflex sensitivity and sympathetic nerve activity in patients with mild heart failure. J. Cardiovasc. Pharmacol. 2002; 40(6): 875-880.</mixed-citation></ref><ref id="B69"><label>69.</label><mixed-citation>Thames M. D., Waickman L. A., Abboud F. M. Sensitization of cardiac receptors (vagal afferents) by intracoronary acetyltrophanthidin. Am. J. Physiol. 1980; 239: H628-H635.</mixed-citation></ref><ref id="B70"><label>70.</label><mixed-citation>Quest J. A., Gillis R. A. Effect of digitalis on carotid sinus baroreceptor activity. Circ. Res. 1974; 35: 247-255.</mixed-citation></ref><ref id="B71"><label>71.</label><mixed-citation>Zucker I. H., Peterson T. V., Gilmore J. P. Ouabain increases left atrial stretch receptor discharge in the dog. J. Pharmacol. Exp. Ther. 1980; 212: 320-324.</mixed-citation></ref><ref id="B72"><label>72.</label><mixed-citation>Thames M. D. Acetylstrophanthidin-induced reflex inhibition of canine renal sympathetic nerve activity mediated by cardiac receptors with vagal afferents. Circ. Res. 1979; 44: 8-15.</mixed-citation></ref><ref id="B73"><label>73.</label><mixed-citation>Krum H., Bigger J. T., Goldsmith R. L., Packer M. Effect of long-term dioxin therapy on autonomic function in patients with chronic heart failure. J. Am. Coll. Cardiol. 1995; 25: 289-294.</mixed-citation></ref><ref id="B74"><label>74.</label><mixed-citation>Feancis J., Weiss R. M., Shun-Guang Wei et al. Central mineralocorticoid receptor blockade improves volume regulation and reduces sympathetic drive in heart failure. Am. J. Physiol. Heart Circ. Physiol. 2001; 281: H2241-H2251.</mixed-citation></ref><ref id="B75"><label>75.</label><mixed-citation>Monahan K. D., Urs A. et al. Aldosterone impairs baroreflex sensitivity in healthy adults. Am. J. Physiol. Heart Circ. Physiol. 2007; 292: H190-H197.</mixed-citation></ref><ref id="B76"><label>76.</label><mixed-citation>Gentlesk P. J., Wiley T., Taylor A. J. A prospective evaluation of the effect of simvastatin on heart rate variability in non-ischemic cardiomyopathy. Am. Heart J. 2005; 150: 478-483.</mixed-citation></ref><ref id="B77"><label>77.</label><mixed-citation>Hamaad A., Sosin M., Lip G. Y., MacFadyen R. J. Short-term adjuvant atorvastatin improves frequency domain induces of heart rate variability in stable systolic heart failure. Cardiovasc. Drugs Ther. 2005; 19: 183-187.</mixed-citation></ref><ref id="B78"><label>78.</label><mixed-citation>Kurian K. C., Rai P., Sankaran S. et al. The effect of statins in heart failure: beyond its cholesterol-lowering effect. J. Card. Fail. 2006; 12: 473-478.</mixed-citation></ref><ref id="B79"><label>79.</label><mixed-citation>Christensen J. H. n-3 fatty acids and the risk of sudden cardiac death: emphasis on heart rate variability. Dan. Med. Bull. 2003; 50: 347-367.</mixed-citation></ref><ref id="B80"><label>80.</label><mixed-citation>Geelen A., Zock P. L., Swenne C. A. et al. Effect of n-3 fatty acids on heart rate variability and baroreflex sensitivity in middle-aged subjects. Am. Heart J. 2003; 146: E4.</mixed-citation></ref><ref id="B81"><label>81.</label><mixed-citation>Pliquett R. U., Cornish K. G., Peuler J. D., Zucker I. H. Simvastatin normalizes autonomic neural control in experimental heart failure. Circulation 2003; 107: 2493-2498.</mixed-citation></ref><ref id="B82"><label>82.</label><mixed-citation>Lie Gao, Wei Wang, Yu-Long Li et al. Simvastatin therapy normalizes sympathetic neural control in experimental heart failure roles of angiotensin II type 1 receptors and NAD(P)H oxidase. Circulation 2005; 112: 1763-1770.</mixed-citation></ref><ref id="B83"><label>83.</label><mixed-citation>Wassmann S., Laufs U., Baumer A. T. et al. Inhibition of geranylgeranylation reduces angiotensin II-mediated free radical production in vascular smooth muscle cells: involvement of angiotensin ATI receptor expression and Rac 1 GTPase. Mol. Pharmacol. 2001; 59: 646-654.</mixed-citation></ref><ref id="B84"><label>84.</label><mixed-citation>Driscoll G., Green D., Taylor R. R. Simvastatin, improves endothelial function within 1 month. Circulation 1997; 95: 1126-1131.</mixed-citation></ref><ref id="B85"><label>85.</label><mixed-citation>Pieker L. E., Corti R., Binggeli C. et al. Baroreceptor dysfunction induced by nitric oxide synthase inhibition in humans. J. Am. Coll. Cardiol. 2000; 36: 213-218.</mixed-citation></ref><ref id="B86"><label>86.</label><mixed-citation>Marchioli R., Barzi F., Bomba E. et al. Early protection against sudden death by n-3 polyunsaturated fatty acids after myocardial infarction. Time-Course Analysis of the Results of the Gruppo Italiano per lo Studio della Sopravvivenza nell'Infarto Miocardico (GISSI)-Prevenzione. Circulation 2002; 105: 1897.</mixed-citation></ref><ref id="B87"><label>87.</label><mixed-citation>Radaelli A., Cazzaniga M., Viola A. et al. Enhanced baroreceptor control of the cardiovascular system by polyunsaturated fatty acids in heart failure patients. J. Am. Coll. Cardiol. 2006; 48: 1600-1606.</mixed-citation></ref><ref id="B88"><label>88.</label><mixed-citation>Giannattasio C., Failla M., Stella M. L. et al. Alterations of radial artery compliance in patients with congestive heart failure. Am. J. Cardiol. 1995; 76: 381-385.</mixed-citation></ref><ref id="B89"><label>89.</label><mixed-citation>Leaf A., Kang J. X., Xiao Y. F. et al. Functional and electrophysiologic effects of polyunsaturated fatty acids on excitable tissues: heart and brain. Prostaglandins Leukot. Essent. Fatty Acids 1999; 60: 307-312.</mixed-citation></ref><ref id="B90"><label>90.</label><mixed-citation>Sola S., Mir M. Q., Lerakis S. et al. Atorvastatin improves left ventricular systolic function and serum markers of inflammation in nonischemic heart failure. J. Am. Coll. Cardiol. 2006; 47: 332-337.</mixed-citation></ref><ref id="B91"><label>91.</label><mixed-citation>La Rovere M. T., Pinna G. D., Maestri R. et al. Short term heart rate variability strongly predicts sudden cardiac death in chronic heart failure patients. Circulation 2003; 107: 565-570.</mixed-citation></ref><ref id="B92"><label>92.</label><mixed-citation>Elkayam U., Amin J., Mehra A. et al. A prospective, randomized, double blind, crossover study to compare the efficacy and safety of chronic nifedipine therapy with that of isosorbide dinitrate and their combination in the treatment of chronic congestive heart failure. Circulation 1990; 82: 1954-1961.</mixed-citation></ref><ref id="B93"><label>93.</label><mixed-citation>Packer M., O'Connor C. M., Ghali J. K. et al. Effect of amlodipine on morbidity and mortality in severe congestive heart failure. N. Engl. J. Med. 1996; 335: 1107-1114.</mixed-citation></ref><ref id="B94"><label>94.</label><mixed-citation>Packer M. Treatment of chronic heart failure. Lancet 1992; 340: 92-95.</mixed-citation></ref><ref id="B95"><label>95.</label><mixed-citation>Grassi G., Spaziani D., Seravalle G. et al. Effects of amlodipine on sympathetic nerve traffic and baroreflex control of circulation in heart failure. Hypertension 1999; 33: 671-675.</mixed-citation></ref><ref id="B96"><label>96.</label><mixed-citation>Hamdan M. H., Zagrodzky J. D., Joglar J. A. et al. Biventricular pacing decreases sympathetic activity compared with right ventricular pacing in patients with depressed ejection fraction. Circulation 2000; 102: 1027-1032.</mixed-citation></ref><ref id="B97"><label>97.</label><mixed-citation>Najem B., Unger P., Preumont N. et al. Sympathetic control after cardiac resynchronization therapy: responders versus nonresponders. A. J. Physiol. Heart Circ. Physiol. 2006; 291: H2647-H2652.</mixed-citation></ref><ref id="B98"><label>98.</label><mixed-citation>Gademan M. G., van Bommel R. J., Ypenburg C. et al. Biventricular pacing in chronic heart failure acutely facilitates the arterial baroreflex. Am. J. Physiol. Heart Circ. Physiol. 2008; 295: H755-H760.</mixed-citation></ref><ref id="B99"><label>99.</label><mixed-citation>Piepoli M. F., Villani G. Q., Corra U. et al. Time course of effects of cardiac resynchronization therapy in chronic heart failure: benefits in patients with preserved exercise capacity. Pacing Clin. Electrophysiol. 2008; 31: 701-708.</mixed-citation></ref><ref id="B100"><label>100.</label><mixed-citation>100. Tjen A. L. S., Pan H. L., Longhurst J. C. Endogenous bradykinin activates ischaemically sensitive cardiac visceral afferents through kinin B2 receptors in cats. J. Physiol. (Lond.) 1998; 510: 633-641.</mixed-citation></ref><ref id="B101"><label>101.</label><mixed-citation>101. Waggoner A. D., Faddis M. N., Gleva M. J. et al. Cardiac resynchronization therapy acutely improves diastolic function. J. Am. Soc. Echocardiogr. 2005; 18: 216-220.</mixed-citation></ref><ref id="B102"><label>102.</label><mixed-citation>102. Gao L., Schultz H. D., Patel K. P. et al. Augmented input from cardiac sympathetic afferents inhibits baroreflex in rats with heart failure. Hypertension 2005; 45: 1173-1181.</mixed-citation></ref><ref id="B103"><label>103.</label><mixed-citation>103. Ruttanaumpawan P., Gilman M. P., Usui K. et al. Sustained effect of continuous positive airway pressure on baroreflex sensitivity in congestive heart failure patients with obstructive sleep apnea. J. Hypertens. 2008; 26(6): 1163-1168.</mixed-citation></ref></ref-list></back></article>
