Terapevticheskii arkhivTerapevticheskii arkhivТерапевтический архив0040-36602309-5342LLC Obyedinennaya Redaktsiya30763Editorial articleПередовая статьяEvidence-based grounds of the efficacy of simvastatin (zocor): 15 years laterДОКАЗАТЕЛЬНАЯ БАЗА ЭФФЕКТИВНОСТИ СИМВАСТАТИНА (ЗОКОРА): 15 ЛЕТ СПУСТЯSusekovAndrey VladimirovichСусековАндрей Владимирович

вед. науч. сотр., отд. возрастных проблем сердечно-сосудистых заболеваний, Институт клинической кардиологии им. А. Л. Мясникова, ФГУ РКНПК Росмедтехнологий, тел.: 8-495-414-69-92; ФГУ Российский кардиологический научно-производственный комплекс Росмедтехнологий

asus99@mail.ruGornyakovaNatal'ya BadrievnaГорняковаНаталья Бадриевна

мл. науч. сотр., отд. возрастных проблем сердечно-сосудистых заболеваний, ИКК им. А. Л. Мясникова, РКНПК Росмедтехнологий, тел.: 8-495-414-65-62; ФГУ Российский кардиологический научно-производственный комплекс Росмедтехнологий

gornyakova@bk.ruZubarevaMarina Yur'evnaЗубареваМарина Юрьевна

мл. науч. сотр., отд. возрастных проблем сердечно-сосудистых заболеваний, ИКК им. А. Л. Мясникова, РКНПК Росмедтехнологий, тел.: 8-495-414-61-64; ФГУ Российский кардиологический научно-производственный комплекс Росмедтехнологий

mzubareva06@mail.ruSusekovA V

Russian Cardiology Research-and-Production Complex, Russian Agency for Medical Technologies

GornyakovaN B

Russian Cardiology Research-and-Production Complex, Russian Agency for Medical Technologies

ZubarevaM Yu

Russian Cardiology Research-and-Production Complex, Russian Agency for Medical Technologies

ФГУ Российский кардиологический научно-производственный комплекс РосмедтехнологийRussian Cardiology Research-and-Production Complex, Russian Agency for Medical Technologies151220108212NO12 (2010)ТОМ 82, №12 (2010)687209042020Copyright ©; 2010, Consilium MedicumCopyright ©; 2010, ООО "Консилиум Медикум"2010Consilium MedicumООО "Консилиум Медикум"https://creativecommons.org/licenses/by-nc-sa/4.0https://ter-arkhiv.ru/0040-3660/article/view/30763

The review describes the history of hypolipidemic therapy with statins. It gives the results of studies of the primary prevention of atherosclerosis and the treatment of hyperlipidemias with lovastatin, pravastatin, and fluvastatin. Emphasis is laid on trial data on the efficacy, tolerability, and safety of simvastatin (zocor). The results of studies, including regression ones, of this drug in different doses, controlled by biochemical, clinical, magnet resonance imaging, and ultrasonic data are summarized. There is a significant reduction in the risk of cardiovascular, coronary, and overall deaths and in that of stroke. There is evidence for the successful use of simvastatin (zocor) in combined therapy with fibrates, nicotinic acid, and ezetrol.

В обзоре освещается история развития гиполипидемической терапии с применением статинов. Приводятся данные о результатах исследований по первичной профилактике атеросклероза и лечению гиперлипидемий с использованием ловастатина, правастатина и флувастатина. Основное внимание уделено данным по эффективности, переносимости и безопасности симвастатина (зокора). Обобщаются результаты исследований, в том числе "регрессионных", этого препарата в различных дозах, контролируемых данными биохимических, клинических, магнитно-резонансных и ультразвуковых методов. Показано достоверное снижение сердечно-сосудистой, коронарной и общей смертности, а также риска развития инсульта. Приводятся сведения об успешном применении симвастатина (зокора) в комбинированной терапии с фибратами, никотиновой кислотой и эзетролом.

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