Terapevticheskii arkhivTerapevticheskii arkhivТерапевтический архив0040-36602309-5342LLC Obyedinennaya Redaktsiya30645Editorial articleПередовая статьяPolyclonal rabbit antithymocyte globulin (thymoglobulin): immunomodulatory effects and new aspects of its clinical applicationПоликлональный кроличий антитимоцитарный глобулин тимоглобулин: иммуномодулирующие эффекты и новые аспекты клинического использованияKulaginA DКулагинАлександр Дмитриевич

кафедра клинической иммунологииканд. мед. наук., доц; ГОУ ВПО "Новосибирский государственный медицинский университет Росздрава"; Novosibirsk State Medical University, Russian Agency for Health Care

кафедра клинической иммунологииканд. мед. наук., доц; ГОУ ВПО "Новосибирский государственный медицинский университет Росздрава"

kulagingem@rambler.ruLisukovI AЛисуковИгорь Андреевич

кафедра клинической иммунологиид-р мед. наук, проф; ГОУ ВПО "Новосибирский государственный медицинский университет Росздрава"; Novosibirsk State Medical University, Russian Agency for Health Care

кафедра клинической иммунологиид-р мед. наук, проф; ГОУ ВПО "Новосибирский государственный медицинский университет Росздрава"

igor_lisukov@mail.ruMiloserdovI AМилосердовИгорь Александрович

Acad. V. I. Shumakov Research Center of Transplantology and Artificial Organs, Ministry of Health and Social Development

канд. мед. наук., ст. науч. сотр., отд-ние клинической трансплантологии; ФГУ "Научный центр трансплантологии и искусственных органов им. акад. В. И. Шумакова" Минздравсоцразвития

kidneytrans@mail.ruAfanasyevB VАфанасьевБорис Владимирович

Acad. I. P. Pavlov Saint Petersburg State Medical University

д-р мед. наук, проф., зав. каф. гематологии, трансфузиологии и трансплантологии; ГОУ ВПО "Санкт-Петербургский государственный медицинский университет им. акад. И. П. Павлова Росздрава"

bmt-director@spmu.rssi.ruNovosibirsk State Medical University, Russian Agency for Health CareГОУ ВПО "Новосибирский государственный медицинский университет Росздрава"Acad. V. I. Shumakov Research Center of Transplantology and Artificial Organs, Ministry of Health and Social DevelopmentФГУ "Научный центр трансплантологии и искусственных органов им. акад. В. И. Шумакова" МинздравсоцразвитияAcad. I. P. Pavlov Saint Petersburg State Medical UniversityГОУ ВПО "Санкт-Петербургский государственный медицинский университет им. акад. И. П. Павлова Росздрава"15072010827NO7 (2010)ТОМ 82, №7 (2010)657209042020Copyright ©; 2010, Consilium MedicumCopyright ©; 2010, ООО "Консилиум Медикум"2010Consilium MedicumООО "Консилиум Медикум"https://creativecommons.org/licenses/by-nc-sa/4.0https://ter-arkhiv.ru/0040-3660/article/view/30645

Antithymocyte immunoglobulins remain to be one of the most effective immunosuppressants used in transplantology and in the treatment of autoimmune diseases. The unique features of the mechanisms of individual antithymocyte globulin preparations should be borne in mind. Due to its polyclonal nature, thymoglobulin provides a wide spectrum of diverse immunomodulatory effects, which is the basis for its wide use in order to reduce the risk for graft rejection and a graft-versus-host reaction and to treat aplastic anemia.

Антитимоцитарные иммуноглобулины остаются одними из наиболее эффективных иммуносупрессивных средств, используемых в трансплантологии и лечении аутоиммунных заболеваний. Следует учитывать наличие уникальных особенностей механизмов действия отдельных препаратов антитимоцитарного глобулина. Благодаря своей поликлональной природе тимоглобулин обеспечивает широкий спектр разнообразных иммуномодуляторных эффектов, что является основанием для его широкого использования в целях снижения риска отторжения трансплантатов и развития реакции трансплантат против хозяина, а также для лечения апластической анемии.

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