Terapevticheskii arkhivTerapevticheskii arkhiv0040-36602309-5342LLC Obyedinennaya Redaktsiya30616Results of hemopoietic cell transplantation in the first complete remission in children with acute myeloid leukemia from an intermediate risk groupDyshlevayaZ MRussian Children's Hospital, Moscow-SkorobogatovaE VRussian Children's Hospital, Moscow-MaschanM AFederal Research and Clinical Centre of Pediatric Hematology, Oncology and Immunology, Ministry of Health of the Russian Federation-ShipitsynaI PRussian Children's Hospital, Moscow-SkvortsovaYu VRussian Children's Hospital, Moscow-TrakhtmanP ERussian Children's Hospital, Moscow-BalashovD NRussian Children's Hospital, Moscow-PashkoYu VRussian Children's Hospital, Moscow-KurnikovaE ERussian Children's Hospital, Moscow-SuntsovaE VRussian Children's Hospital, Moscow-GoronkovaO VRussian Children's Hospital, Moscow-SolopovaG GRussian Children's Hospital, Moscow-BaidildinaD DRussian Children's Hospital, Moscow-KalininaI IRussian Children's Hospital, Moscow-KhachatryanL ARussian Children's Hospital, Moscow-ShneiderM MFederal Research and Clinical Centre of Pediatric Hematology, Oncology and Immunology, Ministry of Health of the Russian Federation-MaschanA AFederal Research and Clinical Centre of Pediatric Hematology, Oncology and Immunology, Ministry of Health of the Russian Federation-Russian Children's Hospital, MoscowFederal Research and Clinical Centre of Pediatric Hematology, Oncology and Immunology, Ministry of Health of the Russian Federation15072010827344009042020Copyright © 2010, Consilium Medicum2010Aim. To analyze the results of allogeneic and autologous hemopoietic cell transplantations (allo- and auto-HCT) in children with acute myeloid leukemia (AML) from an intermediate risk group, most of which were performed using lower-intensity conditioning modes.
Subjects and methods. The study enrolled 36 children from an intermediate risk group, who had undergone auto-HCT (n = 22) or allo-HCT (n = 14) in December 1994 to December 2008. The patients' age was 0.7 to 16.6 years (median 12.8 years). Chemotherapeutic conditioning regimens were applied to all the patients. Melphalan was a basic myeloablative agent in 83.3% of cases.
Results. With a median follow-up of 4.6 years (1.1-13.8 years), three-year relapse-free survival (RFS) was 80.4%; overall survival (OS) was 65.6%. Recurrences were documented only in 6 (16.6%) patients from the auto-HCT. Transplantation-associated mortality (TAM) was 13.8% (five patients died). After allo-HCT versus auto-HCT, RFS, OS, and TAM were 100 and 68.7% (p = 0.03), 93.2 and 55.5% (p = 0.02), and 7.1 and 18.2%, respectively. Acute and chronic graft-versus-host reactions developed in 57.1 and 23.1%, respectively.
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