Terapevticheskii arkhivTerapevticheskii arkhivТерапевтический архив0040-36602309-5342LLC Obyedinennaya Redaktsiya30567Editorial articleПередовая статьяCrohn's disease: Genetic aspectsГенетические аспекты болезни КронаLoranskayaIrina DmitrievnaЛоранскаяИрина Дмитриевна

кафедра гастроэнтерологиизав. каф; ГОУ ДПО "Российская медицинская академия последипломного образования" Росздрава

StepanovaE VСтепановаЕ В

кафедра гастроэнтерологииаспирант; ГОУ ДПО "Российская медицинская академия последипломного образования" Росздрава

LoranskayaI DStepanovaE VГОУ ДПО "Российская медицинская академия последипломного образования" Росздрава15022010822NO2 (2010)ТОМ 82, №2 (2010)667009042020Copyright ©; 2010, Consilium MedicumCopyright ©; 2010, ООО "Консилиум Медикум"2010Consilium MedicumООО "Консилиум Медикум"https://creativecommons.org/licenses/by-nc-sa/4.0https://ter-arkhiv.ru/0040-3660/article/view/30567

The paper deals with the topical problem of modern gastroenterology and coloproctology - the influence of genetic factors on the development and course of Crohn's disease (CD). It presents the data of foreign authors and the results of Russia's first study evaluating the effect of the major polymorphic variants of the NOD2/CARD15 gene predisposing to CD on the risk, course, and other features of CD.

Статья посвящена актуальной проблеме современной гастроэнтерологии и колопроктологии - влиянию генетических факторов на развитие и течение болезни Крона (БК). Представлены данные зарубежных авторов, а также результаты впервые проведенного в России исследования по оценке влияния основных полиморфных вариантов гена предрасположенности к БК NOD2/CARD15 на риск возникновения, характер течения и другие особенности БК.

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