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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="other" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Terapevticheskii arkhiv</journal-id><journal-title-group><journal-title xml:lang="en">Terapevticheskii arkhiv</journal-title><trans-title-group xml:lang="ru"><trans-title>Терапевтический архив</trans-title></trans-title-group></journal-title-group><issn publication-format="print">0040-3660</issn><issn publication-format="electronic">2309-5342</issn><publisher><publisher-name xml:lang="en">LLC Obyedinennaya Redaktsiya</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">30528</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Editorial article</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Передовая статья</subject></subj-group><subj-group subj-group-type="article-type"><subject></subject></subj-group></article-categories><title-group><article-title xml:lang="en">Current views on the pathogenesis of depression and approaches to antidepressive therapy (in case of coaxil)</article-title><trans-title-group xml:lang="ru"><trans-title>Современные представления о патогенезе депрессии и подходы к антидепрессивной терапии (на примере коаксила)</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Tyuvina</surname><given-names>Nina Arkad'evna</given-names></name><name xml:lang="ru"><surname>Тювина</surname><given-names>Нина Аркадьевна</given-names></name></name-alternatives><bio xml:lang="ru"><p>Кафедра психиатрии и медицинской психологиипроф; ММА им. И. М. Сеченова</p></bio><email>natuvina@yandex.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name><surname>Tyuvina</surname><given-names>N A</given-names></name><xref ref-type="aff" rid="aff2"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en"></institution></aff><aff><institution xml:lang="ru">ММА им. И. М. Сеченова</institution></aff></aff-alternatives><aff id="aff2"><institution></institution></aff><pub-date date-type="pub" iso-8601-date="2009-10-15" publication-format="electronic"><day>15</day><month>10</month><year>2009</year></pub-date><volume>81</volume><issue>10</issue><issue-title xml:lang="en">NO10 (2009)</issue-title><issue-title xml:lang="ru">ТОМ 81, №10 (2009)</issue-title><fpage>60</fpage><lpage>64</lpage><history><date date-type="received" iso-8601-date="2020-04-09"><day>09</day><month>04</month><year>2020</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2009, Consilium Medicum</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2009, ООО "Консилиум Медикум"</copyright-statement><copyright-year>2009</copyright-year><copyright-holder xml:lang="en">Consilium Medicum</copyright-holder><copyright-holder xml:lang="ru">ООО "Консилиум Медикум"</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://creativecommons.org/licenses/by-nc-sa/4.0</ali:license_ref></license></permissions><self-uri xlink:href="https://ter-arkhiv.ru/0040-3660/article/view/30528">https://ter-arkhiv.ru/0040-3660/article/view/30528</self-uri><abstract xml:lang="en"><p>The review considers the current theories of depression and its clinical manifestations, as well as the factors that determine the likelihood of depression. It presents information on cerebral structural and functional changes observed in depression. There are data on the tactics of antidepressive therapy as a whole and on the use of coaxil in particular.</p></abstract><trans-abstract xml:lang="ru"><p>В обзоре рассматриваются современные теории развития депрессии и клинические проявления ее, а также факторы, обуслoвливающие вероятность развития депрессии. Приводятся сведения о структурных и функциональных изменениях головного мозга, наблюдаемых при депрессии. Сообщаются данные о тактике антидепрессивной терапии в целом и при применении коаксила в частности.</p></trans-abstract><kwd-group xml:lang="en"><kwd>depression</kwd><kwd>pathogenesis</kwd><kwd>antidepressive therapy</kwd><kwd>coaxil</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>депрессия</kwd><kwd>патогенез</kwd><kwd>антидепрессивная терапия</kwd><kwd>коаксил</kwd></kwd-group></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Kessler R. C., McGonagle K. A., Zhao S, et al. Lifetime and 12-month prevalence of DSM-III-R psychiatric disorders in the United States. Results from the National Comorbidity Survey. Arch. Gen. Psychiatry. 1994; 51: 8-19.</mixed-citation></ref><ref id="B2"><label>2.</label><mixed-citation>Kasper S., McEven B. S. Neurobiological and clinical effects of the antidepressant tianptine. CNS Drugs 2008; 22 (1): 15- 26.</mixed-citation></ref><ref id="B3"><label>3.</label><mixed-citation>Мосолов С. Н. 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