Terapevticheskii arkhivTerapevticheskii arkhiv0040-36602309-5342LLC Obyedinennaya Redaktsiya30510New potentialities in symptom-modifying therapy of osteoarthrosisSalikhovIl'dar Gazimdzhanovich-LapshinaSvetlana Anatol'evnasvetlanalapshina@mail.ruMyasoutovaLeysan Il'darovnamyasoutova74@mail.ruKirillovaElina Rinadovnaelinarin@mail.ruShamsutdinovaNailya Gumerovnanailya@e-diva.ruSalikhovI G-LapshinaS A-MyasoutovaL I-KirillovaE R-ShamsutdinovaN T-15082009818707209042020Copyright © 2009, Consilium Medicum2009Aim. To examine efficacy and tolerance of the drug Bora-Bora in patients with osteoarthrosis.
Material and methods. Bora-Bora and nimesulid were given to 20 patients with a verified diagnosis of osteoarthrosis (OA). 20 control patients received nimesulid alone. Treatment efficacy was evaluated by quantitative parameters of articular syndrome, indices of periarticular muscles affection estimated before the treatment, 2, 6 and 8 weeks after the start of the treatment. Ultrasonic investigation of the joints and periarticular tissues was conducted before and after the treatment course.
Results. The response to Bora-Bora was seen on day 10 of therapy. Bora-Bora attenuated pain syndrome in the joints and periarticular tissues, improved joint function more effectively than nimesulid (p < 0.05). Bora-Bora is a good anelgetic. It is well tolerated and can be recommended for OA treatment.osteoarthrosisprevalencecartilage structure modifying therapyостеоартрозраспространенностьтерапиямодифицирующая структуру хряща[Насонова В. А., Фоломеева О. М., Амирджанова В. Н. и др. Болезни костно-мышечной системы и соединительной ткани в России: динамика статистических показателей за 5 лет (1994-1998). Науч.-практ. ревматол. 2000; 2: 4-12.][Насонов Е. Л. Современные направления фармакотерапии остеоартроза. Consilium Medicum 2004; 3 (9): 408-415.][Насонов Е. Л. Ревматология: мультидисплинарные проблемы. В кн.: Материалы научно-практической конф. "Новое в диагностике и лечении ревматических заболеваний". М.; 2002. 4-9.][Маколкин В. И., Меньшикова И. В. Остеоартроз коленного сустава: современный подход к проблеме лечения. Тер. арх. 2005; 77 (5): 83-86.][Бадокин В. В. Медикаментозная терапия первичного (идиопатического) остеоартроза. Рус. мед. журн. 2003; 11 (5): 243-245.][Nielsen F. H., Hunt C. D., Mullen L. M. et al. Effect of dietary boron on mineral, estrogen, and testosterone metabolism in postmenopausal women. FASEB J. 1987; 1: 394-397.][Nzietchueng R. M., Dousset В., Frank P. et al. Mechanisms implicated in the effects of boron on wound healing. J. Trace Elem. Med. Biol. 2002; 16: 239-244.][Rico H., Crespo E., Hernandes E. R. et al. Influence of boron supplementation on vertebral and femoral bone mass in rats on strenuous treadmill exercise. A morphometric, densitometric and histomorphometric study. J. Clin. Densitom. 2002; 5: 187-192.][Travers R. L., Rennie G. C., Newnham R. E. Boron and arthritis: the result of a double-blind pilotstudy. J. Nutr. Med. 1990; 1: 81-85.]