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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="review-article" dtd-version="1.2" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">Terapevticheskii arkhiv</journal-id><journal-title-group><journal-title xml:lang="en">Terapevticheskii arkhiv</journal-title><trans-title-group xml:lang="ru"><trans-title>Терапевтический архив</trans-title></trans-title-group></journal-title-group><issn publication-format="print">0040-3660</issn><issn publication-format="electronic">2309-5342</issn><publisher><publisher-name xml:lang="en">LLC Obyedinennaya Redaktsiya</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">30248</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Editorial article</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Передовая статья</subject></subj-group><subj-group subj-group-type="article-type"><subject>Review Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">Is it possible to modify the course of chronic obstructive pulmonary disease with modern medication?</article-title><trans-title-group xml:lang="ru"><trans-title>Могут ли современные лекарственные средства модифицировать течение хронической обструктивной болезни легких?</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Avdeev</surname><given-names>S N</given-names></name><name xml:lang="ru"><surname>Авдеев</surname><given-names>С Н</given-names></name></name-alternatives><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff id="aff1"><institution>ФГУ НИИ пульмонологии МЗ РФ, Москва</institution></aff><pub-date date-type="pub" publication-format="electronic" iso-8601-date="2008-08-15"><day>15</day><month>08</month><year>2008</year></pub-date><pub-date date-type="collection"><year>2008</year></pub-date><volume>80</volume><issue>8</issue><issue-title xml:lang="en">VOL 80, NO8 ()</issue-title><issue-title xml:lang="ru">ТОМ 80, №8 (2008)</issue-title><fpage>80</fpage><lpage>86</lpage><history><date date-type="received" iso-8601-date="2020-04-09"><day>09</day><month>04</month><year>2020</year></date></history><pub-history><event event-type="received"><event-desc>Received:<date date-type="received" iso-8601-date="2020-04-09"><day>09</day><month>04</month><year>2020</year></date></event-desc></event><event event-type="pub"><event-desc>Published:<pub-date date-type="pub" publication-format="electronic" iso-8601-date="2008-08-15"><day>15</day><month>08</month><year>2008</year></pub-date></event-desc></event></pub-history><permissions><copyright-statement xml:lang="en">Copyright ©; 2008, Consilium Medicum</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2008, ООО "Консилиум Медикум"</copyright-statement><copyright-year>2008</copyright-year><copyright-holder xml:lang="en">Consilium Medicum</copyright-holder><copyright-holder xml:lang="ru">ООО "Консилиум Медикум"</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://creativecommons.org/licenses/by-nc-sa/4.0</ali:license_ref></license></permissions><self-uri xlink:href="https://ter-arkhiv.ru/0040-3660/article/view/30248">https://ter-arkhiv.ru/0040-3660/article/view/30248</self-uri><abstract xml:lang="ru"><p/></abstract><kwd-group xml:lang="en"><kwd>review</kwd><kwd>chronic obstructive pulmonary disease</kwd><kwd>treatment</kwd><kwd>bronchodilators</kwd><kwd>thiotropium bromide</kwd><kwd>disease modificatio</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>обзор</kwd><kwd>хроническая обструктивная болезнь легких</kwd><kwd>лечение</kwd><kwd>бронходилататоры</kwd><kwd>тиотропия бромид</kwd><kwd>модификация заболевани</kwd></kwd-group></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Global Initiative for Chronic Obstructive Lung Disease (GOLD). 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