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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="other" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Terapevticheskii arkhiv</journal-id><journal-title-group><journal-title xml:lang="en">Terapevticheskii arkhiv</journal-title><trans-title-group xml:lang="ru"><trans-title>Терапевтический архив</trans-title></trans-title-group></journal-title-group><issn publication-format="print">0040-3660</issn><issn publication-format="electronic">2309-5342</issn><publisher><publisher-name xml:lang="en">LLC Obyedinennaya Redaktsiya</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">30005</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Editorial article</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Передовая статья</subject></subj-group><subj-group subj-group-type="article-type"><subject></subject></subj-group></article-categories><title-group><article-title xml:lang="en">From a patient to discovery: a conventional approach to detection of unkown diseases and components of the biological systems</article-title><trans-title-group xml:lang="ru"><trans-title>От больного - к открытию: традиционный путь распознавания ранее неизвестных болезней и компонентов биологических систем</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Barkagan</surname><given-names>Z S</given-names></name><name xml:lang="ru"><surname>Баркаган</surname><given-names>З С</given-names></name></name-alternatives><bio xml:lang="ru"><p>Барнаул; Алтайский филиал ГНЦ РАМН; ЦНИЛ Алтайского медицинского университета</p></bio><xref ref-type="aff" rid="aff1"/><xref ref-type="aff" rid="aff2"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en"></institution></aff><aff><institution xml:lang="ru">Алтайский филиал ГНЦ РАМН</institution></aff></aff-alternatives><aff id="aff2"><institution>ЦНИЛ Алтайского медицинского университета</institution></aff><pub-date date-type="pub" iso-8601-date="2004-07-15" publication-format="electronic"><day>15</day><month>07</month><year>2004</year></pub-date><volume>79</volume><issue>7</issue><issue-title xml:lang="en">NO7 (2004)</issue-title><issue-title xml:lang="ru">ТОМ 79, №7 (2004)</issue-title><fpage>92</fpage><lpage>94</lpage><history><date date-type="received" iso-8601-date="2020-04-09"><day>09</day><month>04</month><year>2020</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2004, Consilium Medicum</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2004, ООО "Консилиум Медикум"</copyright-statement><copyright-year>2004</copyright-year><copyright-holder xml:lang="en">Consilium Medicum</copyright-holder><copyright-holder xml:lang="ru">ООО "Консилиум Медикум"</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://creativecommons.org/licenses/by-nc-sa/4.0</ali:license_ref></license></permissions><self-uri xlink:href="https://ter-arkhiv.ru/0040-3660/article/view/30005">https://ter-arkhiv.ru/0040-3660/article/view/30005</self-uri><abstract xml:lang="en"><p/></abstract><trans-abstract xml:lang="ru"><p/></trans-abstract><kwd-group xml:lang="en"><kwd>coagulation factors</kwd><kwd>hemophilia</kwd><kwd>coagulation</kwd><kwd>bleeding</kwd><kwd>thromboses</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>факторы свертывания</kwd><kwd>гемофилия</kwd><kwd>свертываемость крови</kwd><kwd>кровоточивость</kwd><kwd>тромбозы</kwd></kwd-group></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Schmidt A. 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