<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE root>
<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="other" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Terapevticheskii arkhiv</journal-id><journal-title-group><journal-title xml:lang="en">Terapevticheskii arkhiv</journal-title><trans-title-group xml:lang="ru"><trans-title>Терапевтический архив</trans-title></trans-title-group></journal-title-group><issn publication-format="print">0040-3660</issn><issn publication-format="electronic">2309-5342</issn><publisher><publisher-name xml:lang="en">LLC Obyedinennaya Redaktsiya</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">29978</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Editorial article</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Передовая статья</subject></subj-group><subj-group subj-group-type="article-type"><subject></subject></subj-group></article-categories><title-group><article-title xml:lang="en">Current pathogenetic model of rheumatoid arthritis and its role inclinical practice</article-title><trans-title-group xml:lang="ru"><trans-title>СОВРЕМЕННАЯ МОДЕЛЬ ПАТОГЕНЕЗА РЕВМАТОИДНОГО АРТРИТА И ЕЕ МЕСТОВ КЛИНИЧЕСКОЙ ПРАКТИКЕ</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Suchkov</surname><given-names>S V</given-names></name><name xml:lang="ru"><surname>Сучков</surname><given-names>С В</given-names></name></name-alternatives><bio xml:lang="ru"><p>МОНИКИ им. М. Ф. Владимирского; ММА им. И. М. Сеченова</p></bio><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Khitrov</surname><given-names>A N</given-names></name><name xml:lang="ru"><surname>Хитров</surname><given-names>А Н</given-names></name></name-alternatives><bio xml:lang="ru"><p>ММА им. И. М. Сеченова</p></bio></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Naumova</surname><given-names>T E</given-names></name><name xml:lang="ru"><surname>Наумова</surname><given-names>Т Е</given-names></name></name-alternatives><bio xml:lang="ru"><p>МОНИКИ им. М. Ф. Владимирского</p></bio></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Ogneva</surname><given-names>E A</given-names></name><name xml:lang="ru"><surname>Огнева</surname><given-names>Е А</given-names></name></name-alternatives><bio xml:lang="ru"><p>ЦКБ № 3, Астрахань</p></bio></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Ageev</surname><given-names>V A</given-names></name><name xml:lang="ru"><surname>Агеев</surname><given-names>В А</given-names></name></name-alternatives><bio xml:lang="ru"><p>ЦРБ, Павлово-Посад,Московская область</p></bio></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Gabibov</surname><given-names>A G</given-names></name><name xml:lang="ru"><surname>Габибов</surname><given-names>А Г</given-names></name></name-alternatives><bio xml:lang="ru"><p>Институт биоорганической химии им. М. М. ШемякинаРАН; МГУ им. М. В. Ломоносова</p></bio><xref ref-type="aff" rid="aff6"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Alekberova</surname><given-names>Z S</given-names></name><name xml:lang="ru"><surname>Алекберова</surname><given-names>З С</given-names></name></name-alternatives><bio xml:lang="ru"><p>Институт ревматологии РАМН, Москва</p></bio><xref ref-type="aff" rid="aff7"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en"></institution></aff><aff><institution xml:lang="ru">МОНИКИ им. М. Ф. Владимирского</institution></aff></aff-alternatives><aff-alternatives id="aff2"><aff><institution xml:lang="ru">ММА им. И. М. Сеченова</institution></aff><aff><institution xml:lang="en"></institution></aff></aff-alternatives><aff-alternatives id="aff3"><aff><institution xml:lang="ru">ЦКБ № 3, Астрахань</institution></aff><aff><institution xml:lang="en"></institution></aff></aff-alternatives><aff-alternatives id="aff4"><aff><institution xml:lang="ru">ЦРБ, Павлово-Посад,Московская область</institution></aff><aff><institution xml:lang="en"></institution></aff></aff-alternatives><aff-alternatives id="aff5"><aff><institution xml:lang="ru">Институт биоорганической химии им. М. М. ШемякинаРАН</institution></aff><aff><institution xml:lang="en"></institution></aff></aff-alternatives><aff id="aff6"><institution>МГУ им. М. В. Ломоносова</institution></aff><aff id="aff7"><institution>Институт ревматологии РАМН, Москва</institution></aff><pub-date date-type="pub" iso-8601-date="2004-12-15" publication-format="electronic"><day>15</day><month>12</month><year>2004</year></pub-date><volume>79</volume><issue>12</issue><issue-title xml:lang="en">NO12 (2004)</issue-title><issue-title xml:lang="ru">ТОМ 79, №12 (2004)</issue-title><fpage>83</fpage><lpage>88</lpage><history><date date-type="received" iso-8601-date="2020-04-09"><day>09</day><month>04</month><year>2020</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2004, Consilium Medicum</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2004, ООО "Консилиум Медикум"</copyright-statement><copyright-year>2004</copyright-year><copyright-holder xml:lang="en">Consilium Medicum</copyright-holder><copyright-holder xml:lang="ru">ООО "Консилиум Медикум"</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://creativecommons.org/licenses/by-nc-sa/4.0</ali:license_ref></license></permissions><self-uri xlink:href="https://ter-arkhiv.ru/0040-3660/article/view/29978">https://ter-arkhiv.ru/0040-3660/article/view/29978</self-uri><abstract xml:lang="en"><p/></abstract><trans-abstract xml:lang="ru"><p/></trans-abstract><kwd-group xml:lang="en"><kwd>review</kwd><kwd>rheumatoid arthritis</kwd><kwd>pathogenesis</kwd><kwd>immunodiagnosis</kwd><kwd>immunogenetics</kwd><kwd>cellular mechanisms</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>обзор</kwd><kwd>ревматоидный артрит</kwd><kwd>патогенез</kwd><kwd>иммунодиагностика</kwd><kwd>иммуногенетика</kwd><kwd>клеточные механизмы</kwd></kwd-group></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Davidson A., Diamond В. Autoimmune diseases. N. Engl. J. Med. 2001; 345 (5): 340-350.</mixed-citation></ref><ref id="B2"><label>2.</label><mixed-citation>Cunnane G., Doran M., Bresnihan B. Infections and biological therapy in rheumatoid arthritis. Best Pract. Res. Clin. Rheumatol. 2003; 17 (2): 345-363.</mixed-citation></ref><ref id="B3"><label>3.</label><mixed-citation>Taylor P. С Anti-cytokines and cytokines in the treatment of rheumatoid arthritis. Curr. Pharm. Des. 2003; 9 (14): 1095- 1106.</mixed-citation></ref><ref id="B4"><label>4.</label><mixed-citation>Firestein G. S. Evolving concepts of rheumatoid arthritis. Nature 2003; 423 (6937): 356-361.</mixed-citation></ref><ref id="B5"><label>5.</label><mixed-citation>Nepom G. T. et al. HLA genes associated with rheumatoid arthritis: identification of susceptibility alleles using specific oligonucleotide probes. Arthr. and Rheum. 1989; 32: 15-21.</mixed-citation></ref><ref id="B6"><label>6.</label><mixed-citation>Gonzakz-Juanatey C., Testa A., Garcia-Castelo A. et al. Echocardiographic and Doppler findings in long-term treated rheumatoid arthritis patients without clinically evident cardiovascular disease. Semin. Arthr. Rheum. 2004; 33 (4): 231 - 238.</mixed-citation></ref><ref id="B7"><label>7.</label><mixed-citation>Benoist C., Mathis D. Autoimmunity provoked by infection: how good is the case for T cell epitope mimicry? Nature Immunol. 2001; 2(9): 797-801.</mixed-citation></ref><ref id="B8"><label>8.</label><mixed-citation>Balandraud N., Meynard J. В., Auger I. et al. Epstein-Barr virus load in the peripheral blood of patients with rheumatoid arthritis: accurate quantification using real-time polymerase chain reaction. Arthr. and Rheum. 2003; 48 (5): 1223-1228</mixed-citation></ref><ref id="B9"><label>9.</label><mixed-citation>Salmon M., Gaston J. S. The role of T-lymphocytes in rheumatoid arthritis. Br. Med. Bull. 1995; 51: 332-345.</mixed-citation></ref><ref id="B10"><label>10.</label><mixed-citation>Torres B. A., Johnson H. M. Modulation of disease by superantigens. Curr. Opin. Immunol. 1998; 10: 465-470.</mixed-citation></ref><ref id="B11"><label>11.</label><mixed-citation>Shaw A. S., Dustin M. L. Making the T cell receptor go the distance: a topological view of T cell activation. Immunity 1997; 6: 361-369.</mixed-citation></ref><ref id="B12"><label>12.</label><mixed-citation>Morita Y., Yamamura M., Kawashima M. et al. Flow cytometric single-cell analysis of cytokine prodviction by CD4+ T cells in synovial tissue and peripheral blood from patients with rheumatoid arthritis. Arthr. and Rheum. 1998; 41: 1669-1676.</mixed-citation></ref><ref id="B13"><label>13.</label><mixed-citation>Van der Heijden I. M. et al. Presence of bacterial DNA and bacterial peptidoglycans in joints of patients with rheumatoid arthritis and other arthritides. Arthr. and Rheum. 2000; 43: 593-598.</mixed-citation></ref><ref id="B14"><label>14.</label><mixed-citation>Kang Y. M., Zhang X., Wagner U. G. et al. CD8+ T cells are required for the formation of ectopic germinal centers in rheumatoid synovitis. J. Exp. Med. 2002; 195: 1325-1336.</mixed-citation></ref><ref id="B15"><label>15.</label><mixed-citation>Christopherson K. W., Hromas R. A. Endothelial chemokines in autoimmune disease. Curr. Pharm. Des. 2004; 10 (2): 145- 154.</mixed-citation></ref><ref id="B16"><label>16.</label><mixed-citation>Tussey L., Speller S., Gallimore A., Vessey R. Functionally distinct CD8+ memory T cell subsets in persistent EBV infection are differentiated by migratory receptor expression. Eur. J. Immunol. 2000; 30: 1823-1829.</mixed-citation></ref><ref id="B17"><label>17.</label><mixed-citation>Sallusto F., Lenig D., Forster R. et al. Two subsets of memory T lymphocytes with distinct homing potentials and effector functions. Nature 1999; 401: 708-712.</mixed-citation></ref><ref id="B18"><label>18.</label><mixed-citation>Maldonado A., Mueller Y. M., Thomas P. et al. Decreased effector memory CD45RA+CD62L- CD8+ T cells and increased central memory CD45RA-CD62L+ CD8+ T cells in peripheral blood of rheumatoid arthritis patients. Arthr. Res. Ther. 2003; 5 (2): 91-96.</mixed-citation></ref><ref id="B19"><label>19.</label><mixed-citation>Naor D., Nedvetzki S. Cd44+ in rheumatoid arthritis. Arthr. Res. Ther. 2003; 5 (3): 105-115.</mixed-citation></ref><ref id="B20"><label>20.</label><mixed-citation>Grom A. A. Natural killer cell dysfunction: A common pathway in systemic-onset juvenile rheumatoid arthritis, macrophage activation syndrome, and hemophagocytic lymphohistiocytosis? Arthr. and Rheum. 2004; 50 (3): 689-698.</mixed-citation></ref><ref id="B21"><label>21.</label><mixed-citation>Hammond K. J., Godfrey D. I. NKT cells: potential targets for autoimmune disease therapy? Tissue Antigens 2002; 59 (5): 353-363.</mixed-citation></ref><ref id="B22"><label>22.</label><mixed-citation>Сперанский А. И., Иванова С. М. Аутоиммунные болезни (клинические и теоретические аспекты). Аллергол. и иммунол. 2002; 3 (1): 62-83.</mixed-citation></ref><ref id="B23"><label>23.</label><mixed-citation>D'Cruz D. Testing for autoimmunity in humans. Toxicol. Lett. 2002; 127 (1-3): 93-100.</mixed-citation></ref><ref id="B24"><label>24.</label><mixed-citation>Zhou Z., Menard H. A. Autoantigenic posttranslational modifications of ptoteins: does it apply to rheumatoid arthritis? Curr. Opin. Rheumatol. 2002; 14 (3): 250-253.</mixed-citation></ref><ref id="B25"><label>25.</label><mixed-citation>Сучков С. В. Механизмы цитотоксичности анти-ДНК-аутоантител. Бюл. экспер. биол. 2001; 131 (5): 560-563.</mixed-citation></ref><ref id="B26"><label>26.</label><mixed-citation>Сучков С. В., Габибов А. Г., Гнучев Н. В. ДНК-абзимы и их каталитические свойства. Журн. биол. мед. и фармац. химии. 2001; 3: 114-119.</mixed-citation></ref><ref id="B27"><label>27.</label><mixed-citation>Ohmori H., Капауата N. Mechanisms leading to autoantibody production: link between inflammation and autoimmunity. Curr. Drug Targets Inflamm. Allerg. 2003; 2 (3): 232-241.</mixed-citation></ref><ref id="B28"><label>28.</label><mixed-citation>Smeets T. J. et al. Poor expression of T cell-derived cytokines and activation and proliferation markers in early rheumatoid synovial tissue. Clin. Immunol. Immunopathol. 1998; 88: 84- 90.</mixed-citation></ref><ref id="B29"><label>29.</label><mixed-citation>Dayer J. M. The pivotal role of interleukin-1 in the clinical manifestations of rheumatoid arthritis. Rheumatology 2003; 42 (suppl. 2): 3-10.</mixed-citation></ref><ref id="B30"><label>30.</label><mixed-citation>Bough J. A., Bucala R. Mechanisms for modulating TNF alpha in immune and inflammatory disease. Curr. Opin. Drug Discov. Dev. 2001; 4 (5): 635-650.</mixed-citation></ref><ref id="B31"><label>31.</label><mixed-citation>Brennan F. M., Chantry D., Jackson A., et al. Inhibitory effect of TNF-a antibodies on synovial cell interleukin-1 production in rheumatoid arthritis. Lancet 2001; 2: 244-247.</mixed-citation></ref><ref id="B32"><label>32.</label><mixed-citation>Schuerwegh A. J., Dombrecht E. J., Stevens W. J. et al. Influence of proinflammatory (IL-1-alpha, IL-6, TNF-alpha, IFN- gamma) and anti-inflammatory (IL-4) cytokines on chondrocyte function. Osteoarthr. Cartilage 2003; 11 (9): 681-687.</mixed-citation></ref><ref id="B33"><label>33.</label><mixed-citation>Lubberts E. The role of IL-17 and family members in the pathogenesis of arthritis. Curr. Opin. Invest. Drugs 2003; 4 (5): 572-577.</mixed-citation></ref><ref id="B34"><label>34.</label><mixed-citation>Grade J. A. et al. A proinflammatory role for IL-18 in rheumatoid arthritis. J. Clin. Invest. 1999; 104: 1393-1401.</mixed-citation></ref><ref id="B35"><label>35.</label><mixed-citation>Andersson U., Erlandsson-Harris H. HMGBl is a potent trigger of arthritis. J. Intern. Med. 2004; 255 (3): 344-350.</mixed-citation></ref><ref id="B36"><label>36.</label><mixed-citation>Leech M., Lacey D., Xue J. R. et al. Regulation of p53 by macrophage migration inhibitory factor in inflammatory arthritis. Arthr. and Rheum. 2003; 48 (7): 1881-1889.</mixed-citation></ref><ref id="B37"><label>37.</label><mixed-citation>Schett G. et al. Activation, differential localization, and regulation of the stress-activated protein kinases, extracellular signalregulated kinase, c-JUN N-terminal kinase, and p38 mitogenactivated protein kinase, in synovial tissue and cells in rheumatoid arthritis. Arthr. and Rheum. 2000; 43: 2501-2512.</mixed-citation></ref><ref id="B38"><label>38.</label><mixed-citation>Shiozawa S., Shimizu K., Tanaka K., Hino K. Studies on the contribution of c-fos/AP-1 to arthritic joint destruction. J. Clin. Invest. 1997; 99: 1210-1216.</mixed-citation></ref><ref id="B39"><label>39.</label><mixed-citation>Schultz D. R., Harrington W. J. Apoptosis: programmed cell death at a molecular level. Semin. Arthr. Rheum. 2003; 32 (6): 345-369.</mixed-citation></ref><ref id="B40"><label>40.</label><mixed-citation>Perlman H., Pagliari L. J., Volin M. V. Regulation of apoptosis and cell cycle activity in rheumatoid arthritis. Curr. Mol. Med. 2001; 1 (5): 597-608.</mixed-citation></ref><ref id="B41"><label>41.</label><mixed-citation>Baier A., Meineckel I., Gay S., Pap T. Apoptosis in rheumatoid arthritis. Curr. Opin. Rheumatol. 2003; 15 (3): 274-279.</mixed-citation></ref><ref id="B42"><label>42.</label><mixed-citation>Liu H. et al. TNF-a gene expression in macrophages: regulation by NF-кВ is independent of c-Jun or C/EBPp. J. Immunol. 2000; 164: 4277-4285.</mixed-citation></ref><ref id="B43"><label>43.</label><mixed-citation>Liu H., Perlman H., Pagliari L., Pope R. Constitutively activated Akt-1 is vital for the survival of human monocyte-differentiated macrophages: role of Mcl-1, independent of NF-кВ, Bad or caspase activation. J. Exp. Med. 2001; 194: 113-125.</mixed-citation></ref><ref id="B44"><label>44.</label><mixed-citation>Kirwan J. R. The synovium in rheumatoid arthritis: evidence for (at least) two pathologies. Arthr. and Rheum. 2004; 50 (1): 1-4.</mixed-citation></ref><ref id="B45"><label>45.</label><mixed-citation>Lubberts E. et al. IL-17 promotes bone erosion in murine collagen-induced arthlitis through loss of the receptor activator of NF-кВ ligand/osteoprotegerin balance. J. Immunol. 2003; 170: 2655-2662.</mixed-citation></ref><ref id="B46"><label>46.</label><mixed-citation>Gotdring S. R., Gravallese E. M. Mechanisms of bone loss in inflammatory arthritis: diagnosis and therapeutic implications. Arthr. Res. Ther. 2000; 2: 33-37.</mixed-citation></ref><ref id="B47"><label>47.</label><mixed-citation>Goronzy J. J., Weyand С. М., Ageing, autoimmunity and arthritis T-cell senescence and contraction of T-cell repertoire diversity - catalysts of autoimmunity and chronic inflammation. Arthr. Res. Ther. 2003; 5: 225-234.</mixed-citation></ref><ref id="B48"><label>48.</label><mixed-citation>Sibbitt W. L. Oncogenes, growth factors, and autoimmune diseases (review). Anticancer Res. 1991; 11 (1): 97-113.</mixed-citation></ref><ref id="B49"><label>49.</label><mixed-citation>Imamura F. et al. Monoclonal expansion of synoviocytes in rheumatoid arthritis. Arthr. and Rheum. 1998; 41: 1979-1986.</mixed-citation></ref><ref id="B50"><label>50.</label><mixed-citation>Walsh D. A., Wade M., Mapp P. I., Blake D. R. Focally regulated endothelial proliferation and cell death in human synovium. Am. J. Pathol. 1998; 152: 691-702.</mixed-citation></ref><ref id="B51"><label>51.</label><mixed-citation>Inazuka M. et al. Analysis of p53 tumour suppressor gene somatic mutations in rheumatoid arthritis synovium. Rheumatology 2000; 39: 262-266.</mixed-citation></ref><ref id="B52"><label>52.</label><mixed-citation>Fnoue K., Kumagai C., Nishioka T. et al. Malignant rheumatoid arthritis in the young with polyneuritis as an initial symptom. Nippon Naika Gakkai Zasshi 2004; 83 (1): 134-136.</mixed-citation></ref></ref-list></back></article>
