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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="other" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Terapevticheskii arkhiv</journal-id><journal-title-group><journal-title xml:lang="en">Terapevticheskii arkhiv</journal-title><trans-title-group xml:lang="ru"><trans-title>Терапевтический архив</trans-title></trans-title-group></journal-title-group><issn publication-format="print">0040-3660</issn><issn publication-format="electronic">2309-5342</issn><publisher><publisher-name xml:lang="en">LLC Obyedinennaya Redaktsiya</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">29933</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Editorial article</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Передовая статья</subject></subj-group><subj-group subj-group-type="article-type"><subject></subject></subj-group></article-categories><title-group><article-title xml:lang="en">Erectile dysfunction in patients withischemic heart disease (review)</article-title><trans-title-group xml:lang="ru"><trans-title>Эректильная дисфункция у больныхишемической болезнью сердца (обзор)</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Gamidov</surname><given-names>S I</given-names></name><name xml:lang="ru"><surname>Гамидов</surname><given-names>С И</given-names></name></name-alternatives><bio xml:lang="ru"><p>РГМУ</p></bio><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Mazo</surname><given-names>E В</given-names></name><name xml:lang="ru"><surname>Мазо</surname><given-names>Е Б</given-names></name></name-alternatives><bio xml:lang="ru"><p>РГМУ</p></bio><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Ovchinnikov</surname><given-names>R I</given-names></name><name xml:lang="ru"><surname>Овчинников</surname><given-names>Р И</given-names></name></name-alternatives><bio xml:lang="ru"><p>РГМУ</p></bio><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Kurochkin</surname><given-names>E E</given-names></name><name xml:lang="ru"><surname>Курочкин</surname><given-names>Е Е</given-names></name></name-alternatives><bio xml:lang="ru"><p>РГМУ</p></bio><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Iremashvili</surname><given-names>V V</given-names></name><name xml:lang="ru"><surname>Иремашвили</surname><given-names>В В</given-names></name></name-alternatives><bio xml:lang="ru"><p>РГМУ</p></bio><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en"></institution></aff><aff><institution xml:lang="ru">РГМУ</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2004-03-15" publication-format="electronic"><day>15</day><month>03</month><year>2004</year></pub-date><volume>79</volume><issue>10</issue><issue-title xml:lang="en">NO10 (2004)</issue-title><issue-title xml:lang="ru">ТОМ 79, №10 (2004)</issue-title><fpage>75</fpage><lpage>79</lpage><history><date date-type="received" iso-8601-date="2020-04-09"><day>09</day><month>04</month><year>2020</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2004, Consilium Medicum</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2004, ООО "Консилиум Медикум"</copyright-statement><copyright-year>2004</copyright-year><copyright-holder xml:lang="en">Consilium Medicum</copyright-holder><copyright-holder xml:lang="ru">ООО "Консилиум Медикум"</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://creativecommons.org/licenses/by-nc-sa/4.0</ali:license_ref></license></permissions><self-uri xlink:href="https://ter-arkhiv.ru/0040-3660/article/view/29933">https://ter-arkhiv.ru/0040-3660/article/view/29933</self-uri><abstract xml:lang="en"><p/></abstract><trans-abstract xml:lang="ru"><p/></trans-abstract><kwd-group xml:lang="en"><kwd>review</kwd><kwd>ischemic heart disease</kwd><kwd>arterial hypertention</kwd><kwd>erectile dysfunction</kwd><kwd>treatment</kwd><kwd>PDE-5 inhibitors</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>обзор</kwd><kwd>ишемическая болезнь сердца</kwd><kwd>артериальная гипертония</kwd><kwd>эректильная дисфункция</kwd><kwd>лечение</kwd><kwd>ингибиторы фосфодиэстеразы 5-го типа</kwd></kwd-group></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Braun М., Wassner G., Klotz T. et al. Epidemiology of erectile dysfunction: results of the "Cologne Male Survey". Int. J. Impot. Res. 2000; 12 (6): 305-311.</mixed-citation></ref><ref id="B2"><label>2.</label><mixed-citation>Wabrek A. J., Burchell С Male sexual dysfunction associated with coronary artery disease. Arch. Sex. Behav. 1980; 9: 69- 75.</mixed-citation></ref><ref id="B3"><label>3.</label><mixed-citation>Dhabuwala С. В., Kumar A., Pierce J. M. Myocardial infarction and its influence on male sexual function. Arch. Sex. Behav. 1986; 15: 499-504.</mixed-citation></ref><ref id="B4"><label>4.</label><mixed-citation>Diokno A. C, Brown M. В., Herzog R. Sexual function in the eldery. Arch. Intern. Med. 1990; 150: 197-200.</mixed-citation></ref><ref id="B5"><label>5.</label><mixed-citation>Kirby M., Jackson C, Betteridge J., Friedli K. Is erectile dysfunction a marker for cardiovascular disease? Int. J. Clin. Pract. 2001; 55: 614-618.</mixed-citation></ref><ref id="B6"><label>6.</label><mixed-citation>Kloner R. A., Mullin S. H., Shook T. et al. Erectile dysfunction in the cardiac patient: how common and should we treat? J. Urol. (Baltimore) 2003; 170: 46-50.</mixed-citation></ref><ref id="B7"><label>7.</label><mixed-citation>Montorsi F., Briganti A., Salonia A. et al. Erectile dysfunction prevalence, time of onset and association with risk factors in 300 consecutive patients with acute chest pain and angiographically documented coronary artery disease. Eur. Urol. 2003; 44: 360-365.</mixed-citation></ref><ref id="B8"><label>8.</label><mixed-citation>Greenstein A., Chen J., Miller H. et al. Does severity of ischemic coronary disease correlate with erectile dysfunction?Int. J. Impot. Res. 2001; 9: 123-126.</mixed-citation></ref><ref id="B9"><label>9.</label><mixed-citation>Sullivan M. £., Keoghane S. R., Miller M. A. W. Vascular risk factors and erectile dysfunction. Br. J. Urol. 2001; 87: 838- 845.</mixed-citation></ref><ref id="B10"><label>10.</label><mixed-citation>Feldman H. A., Goldstein I., Hatzichristou D. G. et al. // Impotence and its medical and psychosocial correlates: results of the Massachusetts Male Aging Study. J. Urol. (Baltimore) 1994; 151:54-61.</mixed-citation></ref><ref id="B11"><label>11.</label><mixed-citation>Parazzini F, Menchini F. F, Bortolotti A. et al. Frequency and determinants of erectile dysfunction in Italy. Eur. Urol. 2000; 37: 43-49.</mixed-citation></ref><ref id="B12"><label>12.</label><mixed-citation>Toblli J. E., Stella I., Ferder L. et al. Morphological changes in cavernous tissue in spontaneously hypertensive rats. Am. J. Hypertens. 2000; 13: 686-692.</mixed-citation></ref><ref id="B13"><label>13.</label><mixed-citation>Wassertheil-Smoller S., Blaufox M. D., Oberman A. et al. Effect of antihypertensives on sexual function and quality of life: the TAIM study. Ann. Intern. Med. 1991; 114: 613-620.</mixed-citation></ref><ref id="B14"><label>14.</label><mixed-citation>Арабидзе Г. Г., Арабидзе Pp. Г. Антигипертензивная терапия и половая функция у мужчин. Клин, фармакол. и тер. 1999; 3: 49-52.</mixed-citation></ref><ref id="B15"><label>15.</label><mixed-citation>Саго J. L. L., Vidal L., Vicente J. A. et al. Sexual dysfunction in hypertensive patients treated with losartan. Am. J. Med. Sci. 2001; 321: 336-340.</mixed-citation></ref><ref id="B16"><label>16.</label><mixed-citation>Fogari R., Zoppi A., Poletti L. et al. Sexual activity in hypertensive men treated with valsartan or carvedilol: a crossover study.Am. J. Hypertens. 2001; 14: 27-30.</mixed-citation></ref><ref id="B17"><label>17.</label><mixed-citation>Roumeguere Т., Wespes Е., Carpentier Y. et al. Erectile dysfunction is associated with a high prevalence of hyperlipidemia and coronary heart disease risk. Eur. Urol. 2003; 44: 355-359.</mixed-citation></ref><ref id="B18"><label>18.</label><mixed-citation>Solomon H., Man J. W., Jackson G. Erectile dysfunction and the cardiovascular patient: endothelial dysfunction is the common denominator. Heart 2003; 89: 251-253.</mixed-citation></ref><ref id="B19"><label>19.</label><mixed-citation>Rosen R. C, Weiner D. N. Cardiovascular disease and sleeprelated erections. J. Psychosom. Res. 1997; 42: 515-518.</mixed-citation></ref><ref id="B20"><label>20.</label><mixed-citation>Rizvi K., Hampson J. P., Harvey J. N. Do lipid-lowering drugs cause erectile dysfunction? A systematic review. Fam. Pract. 2002; 19: 95.</mixed-citation></ref><ref id="B21"><label>21.</label><mixed-citation>Shabsigh R., Fishman I. J., Schum С et al. Cigarette smoking and other vascular risk factors in vasculogenic impotence. Urology 1991; 38:227-232.</mixed-citation></ref><ref id="B22"><label>22.</label><mixed-citation>Pittilo R. M. Cigarette smoking and endothelial injury: a review. In: Dana J. N. et al. Tobacco smoking and atherosclerosis. New York: Plenum Press; 1990: 61-78.</mixed-citation></ref><ref id="B23"><label>23.</label><mixed-citation>Mil D. N. Implication of insulin-like growth factors in the pathogenesis of diabetic neuropathy. Brain. Res. Rev. 1995; 20: 47-67.</mixed-citation></ref><ref id="B24"><label>24.</label><mixed-citation>Rosen M. P., Greenfield A. J., Goldstein I. Arteriogenic impotence: findings in 195 impotent men examined with selective internal pudendal angiography. Radiology 1990; 174: 1043- 1050.</mixed-citation></ref><ref id="B25"><label>25.</label><mixed-citation>Solomon H., Man J. W., Jackson G. Erectile dysfunction and the cardiovascular patient: endothelial dysfunction is the common denominator. Heart 2003; 89: 251-253.</mixed-citation></ref><ref id="B26"><label>26.</label><mixed-citation>Mass R., Schwedhelem E., Albseier J., Boger R. H. The pathophysiology of erectile dysfunction related to endothelial dys- function and mediators of vascular function. Vase. Med. 2002; 7: 213-225.</mixed-citation></ref><ref id="B27"><label>27.</label><mixed-citation>О'Kane P. D., Jackson G. Erectile dysfunction: is there silent obstructive coronary artery disease? Int. J. Clin. Pract. 2001; 55: 219-220.</mixed-citation></ref><ref id="B28"><label>28.</label><mixed-citation>Kawanishi Y., Lee K. S., Kimura K. et al. Screening of ischem ic heart disease with cavernous artery blood flow in erectile dysfunctional patients. Int. J. Impot. Res. 2001; 13: 100-102.</mixed-citation></ref><ref id="B29"><label>29.</label><mixed-citation>Kim S. W., Paick J. S., Park D. W. et al. Potential predictors of asymptomatic ischemic heart disease in patients with vasculogenic erectile dysfunction. Urology 2001; 58: 441-445.</mixed-citation></ref><ref id="B30"><label>30.</label><mixed-citation>Hatzichristou D., Hatzimouratidis K, Bekas M. et al. Diagnostic steps in the evaluation of patients with erectile dysfunction. J. Urol. (Baltimore) 2002; 168: 615-620.</mixed-citation></ref><ref id="B31"><label>31.</label><mixed-citation>Montorsi F., Briganti A., Salonia A. et al. Erectile dysfunction prevalence, time of onset and association with risk factors in 300 consecutive patients with acute chest pain and angiographically documented coronary artery disease. Eur. Urol. 2003; 44: 360-365.</mixed-citation></ref><ref id="B32"><label>32.</label><mixed-citation>Montorsi P., Montorsi J., Schulman С. С. Is erectile dysfunction the "tip of the iceberg" of a systemic vascular disorder? Eur. Urol. 2003; 44: 352-354.</mixed-citation></ref><ref id="B33"><label>33.</label><mixed-citation>Lue T. F. Physiology of penile erection and pathophysiology of erectile dysfunction and priapism. In: Cambell's urology. Philadelphia: Saunders; 2002. 1591-1618.</mixed-citation></ref><ref id="B34"><label>34.</label><mixed-citation>Agarwal A., Jain D. С Male sexual dysfunction after stroke. J. Assoc. Physicians India 1989; 37: 505-508.</mixed-citation></ref><ref id="B35"><label>35.</label><mixed-citation>May A. G., DeWeese J. A., Rob С G. Changes in sexual function following operation on the abdominal aorta. Surgery 1969; 65: 41-47.</mixed-citation></ref><ref id="B36"><label>36.</label><mixed-citation>Parzeller M., Raschka C, Bratzke H. Sudden cardiovascular death in correlation with sexual activity: results of a medicolegal postmortem study from 1972-1998. Eur. Heart. J. 2000; 22: 610-611.</mixed-citation></ref><ref id="B37"><label>37.</label><mixed-citation>Drory Y. Sexual activity and cardiovascular risk. Eur. Heart J. 2002; 24 (4, suppl. H): 13-18.</mixed-citation></ref><ref id="B38"><label>38.</label><mixed-citation>Feenstra J., van Drie-Pierik R. J. H. M., Lack С F., StriekerВ. Н. С. Н. Acute myocardial infarction associated with sildenafil. Lancet 1998; 352: 957-958.</mixed-citation></ref><ref id="B39"><label>39.</label><mixed-citation>Palmore E. B. Predictors of the longevity difference: a 25-year followup. Gerontologist 1982; 22: 513-518.</mixed-citation></ref><ref id="B40"><label>40.</label><mixed-citation>Persson G. Five-year mortality in a 70-year-old urban population in relation to psychiatric diagnosis, personality, sexuality and yearly prenatal death. Acta Psychiatr. Scand. 1981; 64: 244-253.</mixed-citation></ref><ref id="B41"><label>41.</label><mixed-citation>Muller J. E., Mittleman A., Maclure M. et al. Triggering myocardial infarction by sexual activity: low absolute risk and prevention by regular physical exertion. Determinants of Myocardial Infarction Onset Study Investigators. J. A. M. A. 1996- 275: 1405-1409.</mixed-citation></ref><ref id="B42"><label>42.</label><mixed-citation>Drory Y., Fisman E. X., Shapiro Y., Pines A. Ventricular ar rhythmias during sexual activity in patients with coronary artery disease. Chest 1996; 109: 922-924.</mixed-citation></ref><ref id="B43"><label>43.</label><mixed-citation>Lue T. F. Erectile dysfunction. N. Engl. J. Med. 2000, 324: 1801-1813.</mixed-citation></ref><ref id="B44"><label>44.</label><mixed-citation>Rotella D. P. Phosphodiesterase 5 inhibitors: current status and potential applications. Nat. Rev. Drug Discov. 2002; 1: 674-682.</mixed-citation></ref><ref id="B45"><label>45.</label><mixed-citation>Montorsi J., Salonia A., Deho F. et al. Pharmacological management of erectile dysfunction. Br. J. Urol. 2003; 91: 446-454.</mixed-citation></ref><ref id="B46"><label>46.</label><mixed-citation>Мазо Е. Б., Дмитриев Д. Г., Гамидов С. И., Овчинников Р. И. Фармакотерапия эректильной дисфункции. Рус. мед. журн. 2001; 9: 1077-1078.</mixed-citation></ref><ref id="B47"><label>47.</label><mixed-citation>Carson С. С. Sildenafil: a 4-year update in the treatment of 20 million erectile dysfunction patients. Curr. Urol. Rep. 2003; 4: 488-496.</mixed-citation></ref><ref id="B48"><label>48.</label><mixed-citation>Corbin J. D., Francis S. H., Webb D. J. Phosphodiesterase type 5 as a pharmacologic target in erectile dysfunction. Urology 2002; 60:4-11.</mixed-citation></ref><ref id="B49"><label>49.</label><mixed-citation>Kloner R. A. Erectile dysfunction in the cardiac patient. Curr. Urol. Rep. 2003; 4: 466-471.</mixed-citation></ref><ref id="B50"><label>50.</label><mixed-citation>Conti С R., Pepine С J., Sweeney M. Efficacy and safety of sildenafil citrate in the treatment of erectile dysfunction in patients with ischemic heart disease. Am. J. Cardiol. 1999; 338: 1397-1404.</mixed-citation></ref><ref id="B51"><label>51.</label><mixed-citation>Kloner R. A., Brown M., Prisant L. M. et al. Effect of sildenafil in patients with erectile dysfunction taking antihypertensive therapy. Sildenafil study group. Am. J. Hypertens. 2001; 14: 70-73.</mixed-citation></ref><ref id="B52"><label>52.</label><mixed-citation>Kloner R. A., Jarow J. P. Erectile dysfunction and sildenafil ci trate and cardiologist. Am. J. Cardiol. 1999; 83: 576-582.</mixed-citation></ref><ref id="B53"><label>53.</label><mixed-citation>Sugiyama A., Satoh Y., Shiina H. et al. Cardiac electrophysiologic and hemodynamic effects of sildenafil, a PDE5 inhibitor, in anesthetized dogs. J. Cardiovasc. Pharmacol. 2001; 38: 940-946.</mixed-citation></ref><ref id="B54"><label>54.</label><mixed-citation>Sofowra G., Dishy V., Roden D. et al. The effect of sildenafil on QT interval in healthy men. Clin. Pharmacol. Ther. 2001; 69 (2): 67.</mixed-citation></ref><ref id="B55"><label>55.</label><mixed-citation>Muller J. E., Mittleman A., Maclure M. et al. Triggering myocardial infarction by sexual activity: low absolute risk and prevention by regular physical exertion. Determinants of Myocardial Infarction Onset Study Investigators. J. A. M. A. 1996; 275: 1405-1409.</mixed-citation></ref><ref id="B56"><label>56.</label><mixed-citation>Emmick J. Т., Stuewe S. R., Mitchell M. Overview of cardiovascular effects of tadalafil. Eur. Heart J. 2002; 24 (4, suppl.): 32-47.</mixed-citation></ref><ref id="B57"><label>57.</label><mixed-citation>Carrier S., Herschorn S., Elhilali M. et al. Cardiovascular safety of Levitra (vardenafil) in patients with erectile dysfunction: an analysis of five placebo-controlled clinical trials. Can. J. Urol. 2003; 10: 1826-1829.</mixed-citation></ref><ref id="B58"><label>58.</label><mixed-citation>Zusman R. M., Pisant L. M., Brown J. M. Effect of sildenafil citrate on blood pressure and heart rate in men with erectile dysfunction taking concomitant antihypertensive medication. J. Hypertens. 2000; 18: 1865-1869.</mixed-citation></ref><ref id="B59"><label>59.</label><mixed-citation>Webb D. J, Freestone S., Allen M. J., Muirhead G. J. Sildenafil citrate and blood pressure-lowering drugs: results of drug interaction studies with an organic nitrate and a calcium antagonist.Am. J. Cardiol. 1999; 83: 21-28.</mixed-citation></ref><ref id="B60"><label>60.</label><mixed-citation>Kloner R. A., Emmick J., Bedding A., Humen D. Pharmacodynamic interactions between tadalafil and nitrates. J. Am. Coll. Cardiol. 2002; 39 (suppl. A): 291.</mixed-citation></ref><ref id="B61"><label>61.</label><mixed-citation>Cheitlin M. D., Nutter A. M., Brindis R. G. et al. ACC/AHA Expert Consensus Document. Use of sildenafil (Viagra) in patients with cardiovascular disease. J. Am. Coll. Cardiol. 1999; 33: 273-282.</mixed-citation></ref><ref id="B62"><label>62.</label><mixed-citation>Feenstra J., van Drie-Pierik R. J. H. M., Lack С F., Strieker В. H. С. Н. Acute myocardial infarction associated with sildenafil. Lancet 1998; 352: 957-958.</mixed-citation></ref><ref id="B63"><label>63.</label><mixed-citation>Arruda-Olson A. M., Mahoney D. W., Nehra A. et al. Cardiovascular effects of sildenafil during exercise in men with known or probable coronary artery disease: a randomized, crossover trial. J. A. M. A. 2002; 287: 719-725.</mixed-citation></ref><ref id="B64"><label>64.</label><mixed-citation>Fox K. M., Thadani U., Ma P. Т., Nash S. D. Time to onset of limiting angina during treadmill exercise in men with erectile dysfunction and stable chronic angina: effect of sildenafil citrate. (Abstract). Circulation 2001; 107: 601-601.</mixed-citation></ref><ref id="B65"><label>65.</label><mixed-citation>Stanopoulos I., Hatzichristou D., Try/on S. et al. Effectrs of sildenafil on cardiopulmonary responses during stress. J. Urol. (Baltimore) 2003; 169: 1417-1421.</mixed-citation></ref><ref id="B66"><label>66.</label><mixed-citation>Thadani U., Smith W., Nash S. et al. Effect of vardenafil on the cardiovascular responses to exercise in men with coronary artery disease. J. Am. Coll. Cardiol. 2002; 40: 2006-2012.</mixed-citation></ref><ref id="B67"><label>67.</label><mixed-citation>Thadani U., Chrysant S., Mazzu A. The effect of vardenafil, a selective PDE-5 inhibitor, on ischemic threshold, exercise tolerance, and circulatory responses during treadmill exercise in men with stable angina pectoris. J. Am. Coll. Cardiol. 2003; 41: 336-339.</mixed-citation></ref><ref id="B68"><label>68.</label><mixed-citation>Padma-Nathan H., Eardley I., Kloner R. A. et al. A 4-year update on the safety of sildenafil citrate (Viagra). Urology 2002: 60 (suppl. 2B): 67-90.</mixed-citation></ref><ref id="B69"><label>69.</label><mixed-citation>Wysomki D. К., Farinas Е., Swartz L. Comparison of re] and expected deaths in sildenafil (Viarga) users. Am. J. &lt; ol. 2002; 89: 13311334.</mixed-citation></ref><ref id="B70"><label>70.</label><mixed-citation>DeBusk R., Drory Y., Goldstein I. et al. Management of dysfunction in patients with cardiovascular disease: recon dations of the Princeton Consensus Panel. Am. J. Ca 2000; 86: 62-68.</mixed-citation></ref></ref-list></back></article>
