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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="other" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Terapevticheskii arkhiv</journal-id><journal-title-group><journal-title xml:lang="en">Terapevticheskii arkhiv</journal-title><trans-title-group xml:lang="ru"><trans-title>Терапевтический архив</trans-title></trans-title-group></journal-title-group><issn publication-format="print">0040-3660</issn><issn publication-format="electronic">2309-5342</issn><publisher><publisher-name xml:lang="en">LLC Obyedinennaya Redaktsiya</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">29908</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Editorial article</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Передовая статья</subject></subj-group><subj-group subj-group-type="article-type"><subject></subject></subj-group></article-categories><title-group><article-title xml:lang="en">Long-term orthostatic and bicycle exercise tests in differential diagnosis of syncopal conditions of unclear origin</article-title><trans-title-group xml:lang="ru"><trans-title>ВОЗМОЖНОСТИ ДЛИТЕЛЬНОЙ ОРТОСТАТИЧЕСКОИ И ВЕЛОЭРГОМЕТРИЧЕСКОИ ПРОБПРИ ДИФФЕРЕНЦИАЛЬНОЙ ДИАГНОСТИКЕ СИНКОПАЛЬНЫХ СОСТОЯНИЙ НЕЯСНОГОГЕНЕЗА</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Pevzner</surname><given-names>A V</given-names></name><name xml:lang="ru"><surname>Певзнер</surname><given-names>А В</given-names></name></name-alternatives><bio xml:lang="ru"><p>Российский кардиологический научно-производственный комплекс МЗ; СР РФ, Москва</p></bio><xref ref-type="aff" rid="aff1"/><xref ref-type="aff" rid="aff3"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Kuchinskaya</surname><given-names>E A</given-names></name><name xml:lang="ru"><surname>Кучинская</surname><given-names>Е А</given-names></name></name-alternatives><bio xml:lang="ru"><p>Российский кардиологический научно-производственный комплекс МЗ; СР РФ, Москва</p></bio><xref ref-type="aff" rid="aff4"/><xref ref-type="aff" rid="aff3"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Vershuta</surname><given-names>E V</given-names></name><name xml:lang="ru"><surname>Вершута</surname><given-names>Е В</given-names></name></name-alternatives><bio xml:lang="ru"><p>Российский кардиологический научно-производственный комплекс МЗ; СР РФ, Москва</p></bio><xref ref-type="aff" rid="aff4"/><xref ref-type="aff" rid="aff3"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Albhskaya</surname><given-names>K V</given-names></name><name xml:lang="ru"><surname>Альбицкая</surname><given-names>К В</given-names></name></name-alternatives><bio xml:lang="ru"><p>Российский кардиологический научно-производственный комплекс МЗ; СР РФ, Москва</p></bio><xref ref-type="aff" rid="aff4"/><xref ref-type="aff" rid="aff3"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Helmets</surname><given-names>G I</given-names></name><name xml:lang="ru"><surname>Хеймец</surname><given-names>Г И</given-names></name></name-alternatives><bio xml:lang="ru"><p>Российский кардиологический научно-производственный комплекс МЗ; СР РФ, Москва</p></bio><xref ref-type="aff" rid="aff4"/><xref ref-type="aff" rid="aff3"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Tripoten</surname><given-names>M I</given-names></name><name xml:lang="ru"><surname>Трипотень</surname><given-names>М И</given-names></name></name-alternatives><bio xml:lang="ru"><p>Российский кардиологический научно-производственный комплекс МЗ; СР РФ, Москва</p></bio><xref ref-type="aff" rid="aff4"/><xref ref-type="aff" rid="aff3"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Moiseeva</surname><given-names>N M</given-names></name><name xml:lang="ru"><surname>Моисеева</surname><given-names>Н М</given-names></name></name-alternatives><bio xml:lang="ru"><p>Российский кардиологический научно-производственный комплекс МЗ; СР РФ, Москва</p></bio><xref ref-type="aff" rid="aff4"/><xref ref-type="aff" rid="aff3"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Rogota</surname><given-names>A N</given-names></name><name xml:lang="ru"><surname>Рогоза</surname><given-names>А Н</given-names></name></name-alternatives><bio xml:lang="ru"><p>Российский кардиологический научно-производственный комплекс МЗ; СР РФ, Москва</p></bio><xref ref-type="aff" rid="aff4"/><xref ref-type="aff" rid="aff3"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Golitsyn</surname><given-names>S P</given-names></name><name xml:lang="ru"><surname>Голицын</surname><given-names>С П</given-names></name></name-alternatives><bio xml:lang="ru"><p>Российский кардиологический научно-производственный комплекс МЗ; СР РФ, Москва</p></bio><xref ref-type="aff" rid="aff4"/><xref ref-type="aff" rid="aff3"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en"></institution></aff><aff><institution xml:lang="ru">Российский кардиологический научно-производственный комплекс МЗ</institution></aff></aff-alternatives><aff-alternatives id="aff2"><aff><institution xml:lang="ru">СР РФ, Москва</institution></aff><aff><institution xml:lang="en"></institution></aff></aff-alternatives><aff id="aff3"><institution>СР РФ, Москва</institution></aff><aff id="aff4"><institution>Российский кардиологический научно-производственный комплекс МЗ</institution></aff><pub-date date-type="pub" iso-8601-date="2004-11-15" publication-format="electronic"><day>15</day><month>11</month><year>2004</year></pub-date><volume>79</volume><issue>11</issue><issue-title xml:lang="en">NO11 (2004)</issue-title><issue-title xml:lang="ru">ТОМ 79, №11 (2004)</issue-title><fpage>23</fpage><lpage>27</lpage><history><date date-type="received" iso-8601-date="2020-04-09"><day>09</day><month>04</month><year>2020</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2004, Consilium Medicum</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2004, ООО "Консилиум Медикум"</copyright-statement><copyright-year>2004</copyright-year><copyright-holder xml:lang="en">Consilium Medicum</copyright-holder><copyright-holder xml:lang="ru">ООО "Консилиум Медикум"</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://creativecommons.org/licenses/by-nc-sa/4.0</ali:license_ref></license></permissions><self-uri xlink:href="https://ter-arkhiv.ru/0040-3660/article/view/29908">https://ter-arkhiv.ru/0040-3660/article/view/29908</self-uri><abstract xml:lang="en"><p>Aim. To study efficiency of bicycle exercise test and long-term orthostatic test in differential diagnosis
of syncopes.
Material and methods. The study included 113 patients suffering from recurrent syncopes of unclear
origin. Twelve healthy volunteers were selected for assessment of the tests specificity. All the patients
and controls were examined by means of long-term orthostatic test (LTOT) and bicycle exercise test
(BET).
Results. Specificity of both tests was 100%,. In LTOT syncopes were observed in 52(46%) cases, including vasovagal syncopes (51 patients), epileptic seizure (1 patient). BET induced vasovagal syncopes in 54(48%) patients. The results of both tests by inducing syncopes coincided in 30 (26%) cases.
In 24(21%o) patients syncopes occurred only in BET while LTOT appeared uninformative. In 21
(18.6%) cases syncopes occurred only in LTOT while BET produced a negative result. 38 (34%) patients had syncopes neither in LTOT nor BET. Both tests induced syncopes in 75 (66%) patients. No
complications were observed.
Conclusion. LTOT and BET are safe and complementary methods in differential diagnosis of syncopes.</p></abstract><trans-abstract xml:lang="ru"><p>Цель исследования. Сравнение возможностей велоэргометрической пробы и длительного ортостатического теста в дифференциальной диагностике обмороков.
Материалы и методы. В исследование включили 113 больных, страдающих рецидивирующими
обмороками неясной природы; 12 здоровых добровольцев выбраны для оценки специфичности
проб. Всем выполнены длительная ортостатическая проба (ДОП) и велоэргометрия (ВЭМ).
Результаты. Специфичность обеих проб составила 100%. При ДОП синкопальные состояния
наблюдались в 52 (46%) случаях, в том числе вазовагальные обмороки в 51 случае, эпилептический припадок в одном. При ВЭМ у 54 (48%) больных индуцированы вазовагальные синкопе.
Результаты обеих проб по индукции синкопе совпали в 30 (26%) случаях. У 24 (21%) больных
обмороки возникали только при ВЭМ, в то время как ДОП оказалась неинформативной. В 21
(18,6%) случае обмороки отмечались только при ДОП, в то время как ВЭМ дала отрицательный результат. У 38 (34%) больных синкопе не наблюдались ни при ДОП, ни при ВЭМ. В
целом с использованием обеих проб обмороки индуцированы у 75 (66%) больных. Ни в одном
случае при проведении ВЭМ и ДОП не наблюдалось осложнений.
Заключение. ДОП и ВЭМ - безопасные и взаимодополняющие методы в дифференциальной
диагностике синкопальных состояний.</p></trans-abstract><kwd-group xml:lang="en"><kwd>syncope</kwd><kwd>vasovagal syncope</kwd><kwd>long-term orthostatic test</kwd><kwd>bicycle exercise test</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>синкопе вазовагальный обморок</kwd><kwd>длительная ортостатическая проба</kwd><kwd>велоэрго- метрическая проба</kwd></kwd-group></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Savage D. D., Corwin L., McGee D. L. et al. Epidemiologic features of isolated syncope: the Framingham study. Stroke 1985; 16: 626-629.</mixed-citation></ref><ref id="B2"><label>2.</label><mixed-citation>Kenny R. A., Ingram A., Bayliss J., Sutton R. Head-up tilt: a useful test for investigating unexplained syncope. Lancet 1986; 1: 1352.</mixed-citation></ref><ref id="B3"><label>3.</label><mixed-citation>Strasberg В., Rechavia E., Sagie A. et al. The head-up tilt table test in patients with syncope of unknown origin. Am. Heart J. 1989; 118: 923.</mixed-citation></ref><ref id="B4"><label>4.</label><mixed-citation>Grubb B. P., Temesy-Armos P., Hahn H., Elliot L. Utility of upright tilt-table testing in the evaluation and management of syncope of unknown origin. Am. J. Med. 1991; 90:6.</mixed-citation></ref><ref id="B5"><label>5.</label><mixed-citation>Del Rosso A., Bartoletti A., Bartoli P. et al. Methodology of head-up tilt testing potentiated with sublingual nitroglycerin in unexplained syncope. Am. J. Cardiol. 2000; 85: 1007-1011.</mixed-citation></ref><ref id="B6"><label>6.</label><mixed-citation>Moya A., Brignole M., Menozzi C. et al. Mechanism of syncope in patients with isolated syncope and in patients with tilt-positive syncope. Circulation 2001; 104: 1261 - 1267.</mixed-citation></ref><ref id="B7"><label>7.</label><mixed-citation>McGrady A., Kern-Buell C., Bush E. et al. Psychological and physiological factors associated with tilt table testing for neurally mediated syncopal syndromes. Pace 2001; 24: 296-301.</mixed-citation></ref><ref id="B8"><label>8.</label><mixed-citation>Theodorakis G. N., Livanis E. G., Leftheriotis D. et al. Head-up tilt test with clomipramine challenge in vasovagal syndrome - a new tilt testing protocol. Eur. Heart J. 2003; 24: 658-663.</mixed-citation></ref><ref id="B9"><label>9.</label><mixed-citation>Sutton R., Bloomfield D. Indications, methodology and classiffication of results of tilt-table testing. Am. J. Cardiol. 1999; 84: 10Q-19Q.</mixed-citation></ref><ref id="B10"><label>10.</label><mixed-citation>Brignole M., Alboni P., Benditt D. et al. Guidelines on management (diagnosis and treatment) of syncope. Eur. Heart J. 2001; 22: 1256-1306.</mixed-citation></ref><ref id="B11"><label>11.</label><mixed-citation>Kapoor W. N. Syncope and hypotension heart disease. In:Braunwald E., ed. A textbook of cardiovascular medicine. 5-th ed. Philadelphia: Saunders Company; 1998. 863-876.</mixed-citation></ref><ref id="B12"><label>12.</label><mixed-citation>Sheffield L. T. In: Braunwald E., ed. A textbook of cardiovascular medicine. 3-th ed. Philadelphia: Saunders Company; 1988. 223-241.</mixed-citation></ref><ref id="B13"><label>13.</label><mixed-citation>Lown В., Graboys Т. В. Management of patients with malignant ventricular arrhythmias. Am. J. Cardiol. 1977; 39 (6): 910-918.</mixed-citation></ref><ref id="B14"><label>14.</label><mixed-citation>Sallis J., Broyles S., Nader P. Blood pressure reactivity to exercise: stability, determination, family aggregation and prediction. J. Dev. Behav. Pediatr. 1991; 12 (3): 162-170.</mixed-citation></ref><ref id="B15"><label>15.</label><mixed-citation>Arad M., Solomon A., Roth A. et al. Postexercise syncope: evidence for increased activity of the sympathetic nervous system. Cardiology 1993; 83: 121-123.</mixed-citation></ref><ref id="B16"><label>16.</label><mixed-citation>Sakaguchi S., Shultz J. J., Remote S. G. et al. Syncope associated with exercise, a manifestation of neurally mediated syncope. Am. J. Cardiol. 1995; 75: 476-481.</mixed-citation></ref><ref id="B17"><label>17.</label><mixed-citation>Calkins H., Seifert M., Morady F. Clinical presentation and longterm follow-up of athletes with exercise-induced vasodepressor syncope. Am. Heart J. 1995; 129: 1159-1163.</mixed-citation></ref><ref id="B18"><label>18.</label><mixed-citation>Yerg J. E., Seals D. Л., Hagberg J. M., Ehsani A. A. Syncope secondary to ventricular asystole in an endurance athlete. Clin. Cardiol. 1986; 9: 220-222.</mixed-citation></ref><ref id="B19"><label>19.</label><mixed-citation>Теппермен Дж., Теппермен X. Физиология обмена веществ и эндокринной системы. М.: Мир; 1989.</mixed-citation></ref></ref-list></back></article>
