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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="other" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Terapevticheskii arkhiv</journal-id><journal-title-group><journal-title xml:lang="en">Terapevticheskii arkhiv</journal-title><trans-title-group xml:lang="ru"><trans-title>Терапевтический архив</trans-title></trans-title-group></journal-title-group><issn publication-format="print">0040-3660</issn><issn publication-format="electronic">2309-5342</issn><publisher><publisher-name xml:lang="en">LLC Obyedinennaya Redaktsiya</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">29759</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Editorial article</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Передовая статья</subject></subj-group><subj-group subj-group-type="article-type"><subject></subject></subj-group></article-categories><title-group><article-title xml:lang="en">Tiotropium bromide: role in the treatment of chronic obstructive pulmonary disease</article-title><trans-title-group xml:lang="ru"><trans-title>Тиотропиума бромид: роль и место при лечении хронических обструктивных болезней легких</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Sinopalnikov</surname><given-names>A I</given-names></name><name xml:lang="ru"><surname>Синопальников</surname><given-names>А И</given-names></name></name-alternatives><bio xml:lang="ru"><p>Москва; Государственный институт усовершенствования врачей МО РФ</p></bio><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en"></institution></aff><aff><institution xml:lang="ru">Государственный институт усовершенствования врачей МО РФ</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2004-03-15" publication-format="electronic"><day>15</day><month>03</month><year>2004</year></pub-date><volume>79</volume><issue>3</issue><issue-title xml:lang="en">NO3 (2004)</issue-title><issue-title xml:lang="ru">ТОМ 79, №3 (2004)</issue-title><fpage>27</fpage><lpage>35</lpage><history><date date-type="received" iso-8601-date="2020-04-09"><day>09</day><month>04</month><year>2020</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2004, Consilium Medicum</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2004, ООО "Консилиум Медикум"</copyright-statement><copyright-year>2004</copyright-year><copyright-holder xml:lang="en">Consilium Medicum</copyright-holder><copyright-holder xml:lang="ru">ООО "Консилиум Медикум"</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://creativecommons.org/licenses/by-nc-sa/4.0</ali:license_ref></license></permissions><self-uri xlink:href="https://ter-arkhiv.ru/0040-3660/article/view/29759">https://ter-arkhiv.ru/0040-3660/article/view/29759</self-uri><abstract xml:lang="en"><p/></abstract><trans-abstract xml:lang="ru"><p/></trans-abstract><kwd-group xml:lang="en"><kwd>chronic obstructive pulmonary diseases</kwd><kwd>treatment</kwd><kwd>tiotropium bromide</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>хронические обструктивные болезни легких</kwd><kwd>лечение</kwd><kwd>тиотропиума бромид</kwd></kwd-group></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Global initiative for chronic obstructive lung disease. Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease. Executive summary. Updated 2003 (www.goldcopd.com)</mixed-citation></ref><ref id="B2"><label>2.</label><mixed-citation>Celli B. R., Benditt J. O., Albert R. K. Chronic obstructive pulmonary disease. In: Albert R., Spiro S., Jett J. (Eds) Comprehensive respiratory medicine. London: Mosby; 2001. 37.1 - 37.24.</mixed-citation></ref><ref id="B3"><label>3.</label><mixed-citation>Iqbal A., Schloss S., George D. et al. Worldwide guidelines for chronic obstructive pulmonary disease: A comparison of diagnosis and treatment recommendations. Respirology 2002; 7: 233-239.</mixed-citation></ref><ref id="B4"><label>4.</label><mixed-citation>Gandevia B. Historical review of the use of parasympatholytic agents in the treatment of respiratory disorders. Postgrad. Med. J. 1975; 51 (suppl. 7): 13-20.</mixed-citation></ref><ref id="B5"><label>5.</label><mixed-citation>Chapman K. R. History of anticholinergic treatment in airways disease. In: Gross N. J. (Ed.) Anticholinergic therapy in obstructive airways disease. London: Franklin Scientific Publications; 1993. 9-17.</mixed-citation></ref><ref id="B6"><label>6.</label><mixed-citation>Barnes P. J. Tiotropium bromide. Expert. Opin. Invest. Drugs 2001; 10: 733-740.</mixed-citation></ref><ref id="B7"><label>7.</label><mixed-citation>Hvizdos K. M., Goa K. L. Tiotropium bromide. Drugs 2002; 62: 1195-1203.</mixed-citation></ref><ref id="B8"><label>8.</label><mixed-citation>Barnes P. J. (3-Agonists, anticholinergics, and other nonsteroid drugs. In: Albert R., Spiro S., Jett J. (Eds) Comprehensive respiratory medicine. London: Mosby; 2001. 34.1-34.10.</mixed-citation></ref><ref id="B9"><label>9.</label><mixed-citation>Hansel Т. Т., Barnes P. J. Tiotropium bromide: a novel oncedaily anticholinergic bronchodilator for the treatment of COPD. Drugs of Today 2002; 38: 585-600.</mixed-citation></ref><ref id="B10"><label>10.</label><mixed-citation>Barnes P. J. Muscarinic receptor subtypes in airways. Life Sci. 1993; 52: 521-528.</mixed-citation></ref><ref id="B11"><label>11.</label><mixed-citation>Eglen R. M., Choppin A., Watson N. Therapeutic opportunities from muscarinic receptor research. Trends Pharmacol. Sci. 2001;22:409-414.</mixed-citation></ref><ref id="B12"><label>12.</label><mixed-citation>Maesen F. P. V., Smeets J. J., Costongs Ma. A. L. et al. Ba 679 Br, a new long-acting antimuscarinic bronchodilator: A pilot dose-escalation study in COPD. Eur. Respir. J. 1993; 6: 1031-1036.</mixed-citation></ref><ref id="B13"><label>13.</label><mixed-citation>Disse В., Speck G. A., Rominger K. L. et al. Tiotropium (Spiriva) mechanistical considerations and clinical profile in obstructive lung disease. Life Sci. 1999; 64: 457-464.</mixed-citation></ref><ref id="B14"><label>14.</label><mixed-citation>Barnes P. J. The pharmacological properties of tiotropium. Chest 2000; 117 (suppl. 2): 63-68.</mixed-citation></ref><ref id="B15"><label>15.</label><mixed-citation>Disse В., Reichi R., Speck G. et a!. A novel long-acting anticholinergic bronchodilator. Life Sci. 1993; 52: 537-544.</mixed-citation></ref><ref id="B16"><label>16.</label><mixed-citation>Haddad E. В., Мак J. С., Barnes P. J. et al. Characterization of [3H]Ba 679 BR, a slowly dissociating muscarinic antagonist, in human lung: Radioligand binding and autoradiograhic maping. Mol. Pharmacol. 1994; 45: 899-907.</mixed-citation></ref><ref id="B17"><label>17.</label><mixed-citation>Nisar M., Euris J. E., Pearson M. G. et al. Acute bronchodilator trials in chronic obstructive pulmonary disease. Am. Rev. Respir. Dis. 1992; 146: 555-559.</mixed-citation></ref><ref id="B18"><label>18.</label><mixed-citation>O'Donnel D. E., Lam M., Webb K. A. Measurement of symptoms, lung hyperinflation and endurance during exercise in chronic obstructive pulmonary disease. Am. J. Respir. Crit. Care Med. 1998; 158: 1557-1565.</mixed-citation></ref><ref id="B19"><label>19.</label><mixed-citation>Casaburi R., Mahler D. A., Jones P. W. et al. A long-term evaluation of once-daily inhaled tiotropium in chronic obstructive pulmonary disease. Eur. Respir. J. 2002; 19: 217-224.</mixed-citation></ref><ref id="B20"><label>20.</label><mixed-citation>Vincken W., van Noord J. A., Greethorst A. P. et al. Improved health outcomes in patients with COPD during 1 year's treatment with tiptropium. Eur. Respir. J. 2002; 19: 209-216.</mixed-citation></ref><ref id="B21"><label>21.</label><mixed-citation>Belman M. J., Botnick W. C., Shin J. W. Inhaled bronchodilators reduce dynamic hyperinflation during exercise in patients with chronic obstructive pulmonary disease. Am. J. Respir. Crit. Care Med. 1996; 153: 967-975.</mixed-citation></ref><ref id="B22"><label>22.</label><mixed-citation>Anthonisen N. R., Connett J. E., Kiley J. P. et al. Effects of smoking intervention and the use of an inhaled anticholinergic bronchodilator on the rate of decline of FEV1. The Lung Health Study. J. A. M. A. 1994; 272: 1497-1505.</mixed-citation></ref><ref id="B23"><label>23.</label><mixed-citation>Leusch A., Eichhorn В., Muller G. et al. Pharmacokinetics and tissue distribution of the anticholinergics tiotropium and ipratropium in the rat and dog. Biopharm. Drug Dispos. 2001; 22: 199-212.</mixed-citation></ref><ref id="B24"><label>24.</label><mixed-citation>Maesen F. P. V., Smeets J. J., Sledsens T. J. H. et al. Tiotropium bromide, a new long-acting antimuscarinic bronchodilator. A pharmacodynamic study in patients with chronic obstructive pulmonary disease. Eur. Respir. J. 1995; 8: 1506- 1513.</mixed-citation></ref><ref id="B25"><label>25.</label><mixed-citation>van Noord J. A., Smeets J. J., Custers F. L. et al. Pharmacodynamic steady state of tiotropium in patients with chronic obstructive pulmonary disease. Eur. Respir. J. 2002; 19: 639- 644.</mixed-citation></ref><ref id="B26"><label>26.</label><mixed-citation>Littner M. R., llowite J. S., Tashkin D. P. et al. Long-acting bronchodilation with once-daily dosing of tiotropium (Spiriva) in stable chronic obstructive pulmonary disease. Am. J. Respir. Crit. Care Med. 2000; 161: 1136-1142.</mixed-citation></ref><ref id="B27"><label>27.</label><mixed-citation>van Noord J. A., Bantje T. A., Eland M. E. et al. A randomized controlled comparison of tiotropium and ipratropium in the treatment of chronic obstructive pulmonary disease. The Dutch Tiotropium Study Group. Thorax 2000; 55: 289-294.</mixed-citation></ref><ref id="B28"><label>28.</label><mixed-citation>Casaburi R., Serby W., Menjoge S. S. et al. The spirometric efficacy of once daily dosing with tiotropium in stable COPD. Am. J. Respir. Crit. Care Med. 1999; 159: A524.</mixed-citation></ref><ref id="B29"><label>29.</label><mixed-citation>Donohue J. F., van Noord J. A., Babeman E. D. et al. A 6month, placebo-controlled comparing lung function and health status changes in COPD patients treated with tiotropium or salmeterol. Chest 2002; 122: 47-55.</mixed-citation></ref><ref id="B30"><label>30.</label><mixed-citation>Tashkin D., Kesten S. Long-term treatment benefits with tiotropium in COPD patients with and without short-term bronchodilator responses. Chest 2003; 123: 1441-1449.</mixed-citation></ref><ref id="B31"><label>31.</label><mixed-citation>Busasco V., Hodder R., Miravitlles M. et al. Health outcomes following treatment for six months with once daily tiotropium compared with twice daily salmeterol in patients with COPD. Thorax 2003; 58: 399-404.</mixed-citation></ref><ref id="B32"><label>32.</label><mixed-citation>Anzueto A., Menjoge S. S., Kesten S. Changes in FEV, over time in 1-year clinical trials of tiotropium in COPD. In: Proceedings of the Annual meeting of the American Thoracic Society (ATS). San Francisco; 2001.</mixed-citation></ref><ref id="B33"><label>33.</label><mixed-citation>Oostenbrink J. В., Rutten-van Molken M., Anton S. et al. A Markov model based on COPD disease severity to analyze the results for a tiotropium trials. Eur. Respir. J. 2002; 20 (suppl. 38): 125S (P 833).</mixed-citation></ref><ref id="B34"><label>34.</label><mixed-citation>Chodosh S., Flanders J. S., Kesten S. et al. Effective delivery of particles with the HandiHaler Dry Powder Inhalation System over a range of chronic obstructive pulmonary disease severity. J. Aerosol. Med. 2001; 14: 309-315.</mixed-citation></ref><ref id="B35"><label>35.</label><mixed-citation>Rand С. S., Nides M., Cowles M. K. et al. Long-term metereddose inhaler adherence in a clinical trial: The Lung Health Study Research Group. Am. J. Respir. Crit. Care Med. 1995; 152: 580-588.</mixed-citation></ref><ref id="B36"><label>36.</label><mixed-citation>Canadian Thoracic Society COPD Guidelines: summary of highlights for family doctors. Can. Respir. J. 2003; 10: 183- 186.</mixed-citation></ref></ref-list></back></article>
