reviewchronic obstructive pulmonary diseasestreatmentthiotropium bromideобзорхронические обструктивные болезни легкихлечениетиотропиум бромид1.Barnes P. J. Muscarinic receptor subtypes in airways. Life Sci. 1993; 52: 521-527.2.Barnes P. J. Bronchodilators: basic pharmacology. In: Carver ley P., Pride N., edrs. Chronic obstructive pulmonary disease. London: Chapman & Hall; 1995. 391-417.3.Disse В., Reichl R., Speck G. et al. Ba679BR, a novel long-acting anticholinergic bronchodilator. Life Sci. 1993; 52: 537- 544.4.Tadjkarimi S., Yacouls M. N. et al. Effect of Ba679BR, a novel longacting anticholinergic agent, on cholinergic neurotransmission in guinea pig and human airways. Am. J. Respir. Crit. Care Med. 1994; 150: 1640-1645.5.Maesen F. P. V., Smeets J. J., Costongs M. A. L. et al. Ba679BK, a new long acting antimuscarinic bronchodilator: a pilot close escalation study in COPD. Eur. Respir. J. 1993; 6: 1031-1036.6.Maesen F. P. V., Smeets J. J., Sledsens T. J. H. et al. Tiotropium bromide, a new long-acting antimuscarinic bronchodilator: a pharmacodynamic study in patients with chronic obstructive pulmonary disease (COPD). Ibid. 1995; 8: 1506- 1513.7.van Noord J. A., Smeets J. J., Custers F. L. I. et al. Pharmacodynamic steady-state of tiotropium in patients with chronic obstructive pulmonary disease. Ibid. 2002; 19: 639-634.8.Casaburi R., Mahler D. A., Jones P. W. et al. A longterm evaluation of once-daily inhaled tiotropium in chronic obstructive pulmonary disease. Ibid. 217-224.9.American Thoracic Society. Standards for the diagnosis and care of patients with chronic obstructive pulmonary disease (COPD). Am. J. Respir. Crit. Care Med. 1995; 152: S77- S120.10.Mahler D. A., Weinberg D. H., Wells С. К., Feinstein A. R. The measurement of dyspnea: contents, interobserver agreement and physiologic correlates of two new clinical indexes. Chest 1984; 85: 751-758.11.Ware J. E., Sherbourne С D. The MOS 36-item short-form health survey (SF-36): I. Conceptual framework and item selection. Med. Care 1992; 30: 472-483.12.Jones P. W., Quirk F. В., Baveystock С. М., Littlejohns P. A selfcomplete measure for chronic airflow limitation - the St George's Respiratory Questionnaire. Am. Rev. Respir. Dis. 1992; 145: 1321-1327.13.Vincken W., van Noord J. A., Greefhorst A. R. M. et al. Improved health outcomes in patients with COPD during I yr's treatment with tiotropium. Eur. Respir. J. 2002; 19: 209-216.14.Global initiative for chronic obstructive lung disease. Jeneva: WHO; 2002.15.Donahue J. F., van Noord J. A., Bateman E. D. et al. A 6month, placebo-controlled study comparing lung function and health status changes in COPD patients treated with tiotropium or salmeterol. Chest 2002; 122: 47-55.