reviewendothelial dysfunctionnitric oxidecoronary heart diseaseобзордисфункция эндотелияоксид азотаишемическая болезнь сердца1.Ludmer P. L., Selwyn A. P., Shook Т. L. et al. Paradoxical vasoconstriction induced by acetylcholine in atherosclerotic coronary arteries. N. Engl. J. Med. 1986; 315: 1046 1051.2.Furchgott R. F., Zawadzki J. V. The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine. Nature 1980; 288: 373-376.3.Palmer R. M. J., Ashton D. S., Moncada S. Vascular endothelial cells synthesize nitric oxide from L-arginine. Ibid. 1988; 333: 664-666.4.Vanhoutte P. M. The endothelium. Modulator of vascular smooth muscle tone. N. Engl. J. Med. 1988; 319: 512-513.5.Yasue H., Matsuyama K., Okumura K. et al. Responses of angiographically normal human coronary arteries to intracorinary injection of acetylcholine by age and segment. Possible role of early atherosclerosis. Circulation 1990; 81: 482-490.6.Nitenberg A., Antony I., Foult J. M. Acetylcholine-induced coronary vasoconstriction in young, heavy smokers with normal coronary arteriographic findings. Am. J. Med. 1993; 95: 71 - 77.7.Casino P. R., Kilcoyne С. М., Guyyumi A. A. et al. Investigation of decreased availability of nitric oxide precursor as a mechanism responsible for impaired endothelium-dependent vasodilation in hypercholesterolemic patients. J. Am. Coll. Cardiol. 1994; 23: 844-850.8.Egashira R., Hirooka Y., Kai H. et al. Reduction in serum cholesterol with pravastatin improves endothelium-dependent coronary vasomotion in patients with hypercholesterolemia. Circulation 1994; 89: 2519-2524.9.Treasure С. В., Klein К. J., Wemtreub W. S. et al. Beneficial effects of cholesterol lowering therapy on the coronary endothelium in patients with coronary artery disease. N. Engl. J. Med. 1995;332:481-487.10.Leiher A. M., Dexter H., Saurbier В., Just H. Endothelium-mediated coronary blood flow modulation in humans: effects of age, atherosclerosis, hypercholesterolemia, and hypertension. J. Clin Invest. 1993; 92: 652-662.11.Panza J. A., Guyyumi A. A., Callahan Т. S., Epstein S. E. Effect of hypertensive treatment on endothelium-dependent vascular relaxation in patients with essential hypertension. J. Am. Coll. Cardiol. 1993; 21: 1145-1151.12.Petros A. J., Hewlett A. M., Bogle R. G., Pearson J. D. L-arginine induced hypotension. (Letter). Lancet 1991; 337: 1044-1045.13.Hodgson J. Mc. В., Marshall J. Direct vasoconstriction and endothelium- dependent vasodilatation: Mechanisms of acetylcholine effects on coronary flow and arterial diameter in patients with nonstenotic coronary arteries. Circulation 1989; 79: 1043-1051.14.Ryan Jr. T. J., Treasure С. В., Yeung A. C. et al. Impaired endothelium-dependent dilatation of the coronary microvasculature in patients with atherosclerosis. Ibid. 1991; 84 (suppl. II): 11-624.15.Tousoulis D., Tentolouris C., Crake T. et al. Basal and frowmediated nitric oxide production by atheromatous coronary arteries. J. Am. Coll. Cardiol. 1997; 29: 1256-1262.16.Quyyumic J. S., Dakak N., Andrews N. E. et al. Contribution of nitric oxide to metaboli coronary vasodilatation in the human heart. Circulation 1995; 92: 320-326.17.Yao S. K, Akhtar S., Scott-Burden T. et al. Endogenous and exogenous nitric oxide protect against intracoronary thrombosis and reocclusion after thrombolysis. Ibid. 1005-1010.18.Мазур Н. А. Небилет (небивалол): Клиническая фармакология и международный опыт применения. М., 2000. 54.19.Maneini G. В., Henry G. С., Macaja С. et al. Angiotensinconverting enzyme inhibition with guinapril improves endothelial vasomotor dysfunction in patients with coronary artery disease. The TREND (Trial on Reversing Endothelial Dysfunction) study. Circulation 1996; 94: 258-265.20.Verhaar M., Honing L. H. H., van Dam T. et al. Nifedipine improves NO mediated vasodilatation in hypercholesterolemia, independent of an effect on blood pressure and plasma lipids. Circulation 1998; 98 (suppl.): 1-243.21.Treasure С. В., Klein J. L., Wentraub W. S. et al. Beneficial effects of cholesteroll owering therapy on the coronary endothelium in patients with coronary artery disease. N. Engl. J. Med. 1995; 332: 481-487.