Terapevticheskii arkhivTerapevticheskii arkhiv0040-36602309-5342LLC Obyedinennaya Redaktsiya29293Efficacy of anti-inflammatory treatment with benacort of patients with chronic obstructive pulmonary disease in exacerbationKolesnikovV V-KorolchukI S-15012003781555809042020Copyright © 2003, Consilium Medicum2003Aim. To determine a course and prognostic effectiveness of corticosteroid therapy of chronic obstructive
pulmonary disease (COPD).
Material and methods. Long-term therapy with broncholytics (berodual) and benacort was given to
25 patients in non-infectious exacerbation, 20 patients received broncholitics of 45 COPD patients
with mild and moderate ventilation disorders. Follow-up lasted for 2.5 years. Treatment effectiveness
was judged by clinical indices, external respiration function, parameters of systemic immunity, cyto-
gram of induced sputum and concentration of inflammatory markers in the sputum.
Results. An immediate effect of two-month therapy with benacort of COPD exacerbations manifested
with positive clinical dynamics and relief of endobronchial inflammation. Prognostic efficacy - with a
significant reduction of the frequency of COPD exacerbations and of their mean duration more than
3-fold.
Conclusion. The results of long-term follow-up support validity of inhalation corticosteroids use for
eradication and prevention of noninfectious exacerbations of COPD.chronic obstructive pulmonary diseaseexacerbationefficacy of inhalation therapybenacortprognosisхроническая обструктивная болезнь легкихобострениеэффективность ингаляционной терапиибенакортпрогноз[Ball P. Epidemiology and treatment of chronic bronchitis and its exacerbations. Chest 1995; 108(2): 43-52.][Well С. Epidemiology of COPD in general practice. In: COPD: diagnosis and treatment. Geneva: Excerpta Medica; 1996. 18-24.][Чучалин А. Г. Хронические обструктивные болезни легких. М.: Изд-во БИНОМ; 1999.][Александрова Н. И. Лечение хронической обструктивной болезни легких. В кн.: Новые направления в пульмонологии. Краснодар; Анапа; 1996. 37-39.][Клячкин Л. М. Реабилитация в пульмонологии. Пульмонология 1994; I: 6-9.][Елисеев О. М. Хронические обструктивные болезни легких: Нац. программа. Тер. арх. 1999; 5: 78-80.][Barnes P. J. Chronic obstructive pulmonary disease. N. Engl. J. Med. 2000; 343(4): 269-280.][Siafakas N. M., Vermeire P., Pride N. B. et al. Optimal assessment and management of chronic obstructive pulmonary disease (COPD). A consensus statement of the European Respiratory Society (ERS). Eur. Respir. J. 1995; 8: 1398-1420.][Vestbo J., Sorensen Т., Lange P. et al. Long-term effects of budesonide in mild and moderate in chronic obstructive pulmobary disease: a randomised controlles trial. Lancet 1999; 353: 1819-1823.][Cross N. J. COPD management: the question of steroids. J. Respir. Dis. 1996; 17: 299-303.][Vitacca M., Clini E., Porta R., Foglio K. Acute exacerbations in patients with COPD: predictors of need for mechanical ventilation. Eur. Respir J. 1996; 9: 1487-1493.][Pizzichini E., Pizzichini M. M., Efthimiadis A. et al. Measurement of inflammatory indices in induced sputum: effects od selection of sputum to minimize salivary contamination. Ibid. 1174-1180.][Popov T. A., Pizzichini M. M., Pizzichini E. et al. Some technical factors influencing the induction of sputum for cell analysis. Ibid. 1995; 8(4): 559-565.][Нестерова И. В., Тараканов В. А., Слынько Л. И. Тестирование состояния микробицидной системы нейтрофильных гранулоцитов в диагностике синдрома иммунного дефицита: Метод, рекомендации Краснодар; 1992.]