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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="research-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Terapevticheskii arkhiv</journal-id><journal-title-group><journal-title xml:lang="en">Terapevticheskii arkhiv</journal-title><trans-title-group xml:lang="ru"><trans-title>Терапевтический архив</trans-title></trans-title-group></journal-title-group><issn publication-format="print">0040-3660</issn><issn publication-format="electronic">2309-5342</issn><publisher><publisher-name xml:lang="en">LLC Obyedinennaya Redaktsiya</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">109956</article-id><article-id pub-id-type="doi">10.26442/00403660.2022.10.201878</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Original articles</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Оригинальные статьи</subject></subj-group><subj-group subj-group-type="article-type"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">Body composition in sarcopenia in middle-aged individuals</article-title><trans-title-group xml:lang="ru"><trans-title>Композиционный состав тела при саркопении у лиц среднего возраста</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-2667-4842</contrib-id><name-alternatives><name xml:lang="en"><surname>Samoilova</surname><given-names>Iuliia G.</given-names></name><name xml:lang="ru"><surname>Самойлова</surname><given-names>Юлия Геннадьевна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="ru"><p>д-р мед. наук, зав. каф. детских болезней, проф. каф. факультетской терапии с курсом клинической фармакологии ФГБОУ ВО СибГМУ</p></bio><email>samoilova_y@inbox.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-9966-6686</contrib-id><name-alternatives><name xml:lang="en"><surname>Matveeva</surname><given-names>Mariia V.</given-names></name><name xml:lang="ru"><surname>Матвеева</surname><given-names>Мария Владимировна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="ru"><p>д-р мед. наук, доц. каф. детских болезней, доц. каф. общей врачебной практики и поликлинической терапии ФГБОУ ВО СибГМУ</p></bio><email>matveeva.mariia@yandex.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-3596-6732</contrib-id><name-alternatives><name xml:lang="en"><surname>Khoroshunova</surname><given-names>Ekaterina A.</given-names></name><name xml:lang="ru"><surname>Хорошунова</surname><given-names>Екатерина Анатольевна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="ru"><p>аспирант каф. организации здравоохранения ФГБОУ ВО СибГМУ</p></bio><email>katya.xoroshunova.96@bk.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-4212-3848</contrib-id><name-alternatives><name xml:lang="en"><surname>Kudlay</surname><given-names>Dmitrii A.</given-names></name><name xml:lang="ru"><surname>Кудлай</surname><given-names>Дмитрий Анатольевич</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="ru"><p>чл.-кор. РАН, д-р мед. наук, проф. каф. фармакологии Института фармации им. А.П. Нелюбина ФГАОУ ВО «Первый МГМУ им. И.М. Сеченова» (Сеченовский Университет), вед. науч. сотр. лаб. персонализированной медицины и молекулярной иммунологии №71 ФГБУ ГНЦ «Институт иммунологии»</p></bio><email>kudlay_d_a@staff.sechenov.ru</email><xref ref-type="aff" rid="aff2"/><xref ref-type="aff" rid="aff3"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-2888-5539</contrib-id><name-alternatives><name xml:lang="en"><surname>Tolmachev</surname><given-names>Ivan V.</given-names></name><name xml:lang="ru"><surname>Толмачев</surname><given-names>Иван Владиславович</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="ru"><p>канд. мед. наук, доц. каф. медицинской и биологической кибернетики ФГБОУ ВО СибГМУ</p></bio><email>kaf.med.kiber@ssmu.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-5269-736X</contrib-id><name-alternatives><name xml:lang="en"><surname>Spirina</surname><given-names>Ludmila V.</given-names></name><name xml:lang="ru"><surname>Спирина</surname><given-names>Людмила Викторовна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="ru"><p>д-р мед. наук, зав. каф., проф. каф. биохимии и молекулярной биологии с курсом клинической лабораторной диагностики ФГБОУ ВО СибГМУ, вед. науч. сотр. отд-ния биохимии опухоли Научно-исследовательского института онкологии ФГБНУ «Томский НИМЦ»</p></bio><email>kaf.biohimia@ssmu.ru</email><xref ref-type="aff" rid="aff1"/><xref ref-type="aff" rid="aff4"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-8104-4325</contrib-id><name-alternatives><name xml:lang="en"><surname>Mosienko</surname><given-names>Igor V.</given-names></name><name xml:lang="ru"><surname>Мосиенко</surname><given-names>Игорь Владимирович</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="ru"><p>врач-эндокринолог ФГБОУ ВО СибГМУ</p></bio><email>bolone08@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-9127-8619</contrib-id><name-alternatives><name xml:lang="en"><surname>Yun</surname><given-names>Vera E.</given-names></name><name xml:lang="ru"><surname>Юн</surname><given-names>Вера Эдуардовна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="ru"><p>ассистент каф. педиатрии с курсом эндокринологии ФГБОУ ВО СибГМУ</p></bio><email>verayun05@mail.com</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-2825-5035</contrib-id><name-alternatives><name xml:lang="en"><surname>Trifonova</surname><given-names>Ekaterina I.</given-names></name><name xml:lang="ru"><surname>Трифонова</surname><given-names>Екатерина Ивановна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="ru"><p>ординатор каф. педиатрии с курсом эндокринологии ФГБОУ ВО СибГМУ</p></bio><email>trif18kate@gmail.com</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-9809-4716</contrib-id><name-alternatives><name xml:lang="en"><surname>Zakharchuk</surname><given-names>Polina I.</given-names></name><name xml:lang="ru"><surname>Захарчук</surname><given-names>Полина Игоревна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="ru"><p>студентка ФГБОУ ВО СибГМУ</p></bio><email>polya@yandex.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-6384-1972</contrib-id><name-alternatives><name xml:lang="en"><surname>Vachadze</surname><given-names>Tamara D.</given-names></name><name xml:lang="ru"><surname>Вачадзе</surname><given-names>Тамара Джамбуловна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="ru"><p>студентка ФГБОУ ВО СибГМУ</p></bio><email>vtooma@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-5299-2097</contrib-id><name-alternatives><name xml:lang="en"><surname>Shuliko</surname><given-names>Liudmila M.</given-names></name><name xml:lang="ru"><surname>Шулико</surname><given-names>Людмила Михайловна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="ru"><p>студентка ФГБОУ ВО СибГМУ</p></bio><email>ludmila.shuliko15@gmail.com</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-2660-469X</contrib-id><name-alternatives><name xml:lang="en"><surname>Galiukova</surname><given-names>Daria E.</given-names></name><name xml:lang="ru"><surname>Галюкова</surname><given-names>Дарья Евгеньевна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="ru"><p>студентка ФГБОУ ВО СибГМУ</p></bio><email>darya.galyukova@yandex.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-2816-5547</contrib-id><name-alternatives><name xml:lang="en"><surname>Mutalimi</surname><given-names>Venera E.</given-names></name><name xml:lang="ru"><surname>Муталими</surname><given-names>Венера Эльдаровна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="ru"><p>врач-педиатр, ассистент каф. педиатрии с курсом эндокринологии ФГБОУ ВО СибГМУ</p></bio><email>mutalimivenera@yandex.ru</email><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Siberian State Medical University</institution></aff><aff><institution xml:lang="ru">ФГБОУ ВО «Сибирский государственный медицинский университет» Минздрава России</institution></aff></aff-alternatives><aff-alternatives id="aff2"><aff><institution xml:lang="en">Sechenov First Moscow State Medical University (Sechenov University)</institution></aff><aff><institution xml:lang="ru">ФГАОУ ВО «Первый Московский государственный медицинский университет им. И.М. Сеченова» Минздрава России (Сеченовский Университет)</institution></aff></aff-alternatives><aff-alternatives id="aff3"><aff><institution xml:lang="en">National Research Center – Institute of Immunology</institution></aff><aff><institution xml:lang="ru">ФГБУ «Государственный научный центр “Институт иммунологии”» ФМБА России</institution></aff></aff-alternatives><aff-alternatives id="aff4"><aff><institution xml:lang="en">Cancer Research Institute of Tomsk National Research Medical Center of the Russian Academy of Sciences (Tomsk NRMC)</institution></aff><aff><institution xml:lang="ru">Научно-исследовательский институт онкологии ФГБНУ «Томский национальный исследовательский медицинский центр» РАН</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2022-11-22" publication-format="electronic"><day>22</day><month>11</month><year>2022</year></pub-date><volume>94</volume><issue>10</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><fpage>1149</fpage><lpage>1154</lpage><history><date date-type="received" iso-8601-date="2022-08-23"><day>23</day><month>08</month><year>2022</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2022, Consilium Medicum</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2022, ООО "Консилиум Медикум"</copyright-statement><copyright-year>2022</copyright-year><copyright-holder xml:lang="en">Consilium Medicum</copyright-holder><copyright-holder xml:lang="ru">ООО "Консилиум Медикум"</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://creativecommons.org/licenses/by-nc-sa/4.0</ali:license_ref></license></permissions><self-uri xlink:href="https://ter-arkhiv.ru/0040-3660/article/view/109956">https://ter-arkhiv.ru/0040-3660/article/view/109956</self-uri><abstract xml:lang="en"><p>Sarcopenia is characterized by a progressive loss of muscle mass, strength, and function, leading to poor outcomes and reduced quality of life. In middle age, the decrease in muscle mass begins to be progressive. Bioimpedancemetry allows diagnosing this condition before the onset of clinical symptoms.</p> <p><bold>The purpose of the study: </bold>to evaluate the parameters of body composition in the early diagnosis of sarcopenia in middle-aged people.</p> <p><bold>Materials and Methods: </bold>The participants were divided into two groups – the main one with sarcopenia – 146 people and the control group – 75 people. The complex of examinations included: neuropsychological testing (Hospital Anxiety and Depression Scale (HADS), quality of life questionnaire for patients with sarcopenia (SarQoL), short health assessment form (SF-36)), 4-meter walking speed test, dynamometry and bioimpedancemetry.</p> <p><bold>The results</bold> of neuropsychological examination did not differ in the main and control groups. Patients with sarcopenia showed a decrease in muscle strength according to dynamometry. The scores of the walking speed assessment test in the study group were significantly higher than in the control group. The main and control groups had excessive body weight. According to the results of bioimpedanceometry, the main group had increased fat mass, percentage of fat mass, visceral fat area, and fat mass index compared with the control group. Skeletal muscle mass was less in the main group, probable sarcopenia was confirmed by decreased appendicular mass, decreased protein and mineral content was also recorded. There was a more pronounced decrease in cell mass in the main group. In patients with sarcopenia the volume of intracellular and extracellular fluid was less than in the control group. Significant differences were considered at <italic>p</italic>&lt;0.05.</p> <p><bold>Conclusions:</bold> the introduction of bioimpedancemetry and dynamometry into early screening for muscle mass reduction will allow timely start of therapeutic and preventive measures even in middle age, which will lead to a decrease in the progression of sarcopenia in the elderly, as well as improve the quality of life.</p></abstract><trans-abstract xml:lang="ru"><p>Саркопения характеризуется прогрессирующей потерей мышечной массы, силы и функции мышц, что приводит к неблагоприятным исходам и снижению качества жизни. Снижение мышечной массы начинает носить прогрессирующий характер в среднем возрасте. Биоимпедансометрия позволяет диагностировать данное состояние до возникновения клинических симптомов.</p> <p><bold>Цель.</bold> Оценка параметров композиционного состава тела в ранней диагностике саркопении у лиц среднего возраста.</p> <p><bold>Материалы и методы. </bold>Участники разделены на 2 группы: основную (с саркопенией) – 146 человек и контрольную – 75 человек. Комплекс обследований включал: нейропсихологическое тестирование [Госпитальная шкала тревоги и депрессии (HADS), опросник качества жизни для пациентов с саркопенией (SarQoL), краткая форма оценки здоровья (SF-36)], тест оценки скорости ходьбы на 6 м, динамометрию и биоимпедансометрию.</p> <p><bold>Результаты</bold> нейропсихологического исследования не отличались в основной и контрольной группах. У больных с саркопенией отмечается снижение мышечной силы по данным динамометрии. Показатели теста оценки скорости ходьбы в основной группе оказались значительно выше, чем в контрольной. Пациенты основной и контрольной групп имели избыточную массу тела. По результатам биоимпедансометрии в основной группе по сравнению с контрольной отмечалось повышение жировой массы, процента жировой массы, площади висцерального жира, индекса жировой массы. Масса скелетной мускулатуры в основной группе была меньше, вероятная саркопения подтверждалась уменьшением аппендикулярной массы, также регистрировали снижение содержания протеинов и минералов. Отмечается более выраженное снижение клеточной массы в основной группе. У пациентов с саркопенией объем внутриклеточной и внеклеточной жидкости был меньше, чем в контрольной. Достоверными считались различия при <italic>р</italic>&lt;0,05.</p> <p><bold>Заключение. </bold>Внедрение в ранний скрининг снижения мышечной массы биоимпедансометрии и динамометрии позволит своевременно начать лечебно-профилактические мероприятия еще в среднем возрасте, что приведет к уменьшению прогрессирования саркопении у пожилых людей, а также улучшит качество жизни.</p></trans-abstract><kwd-group xml:lang="en"><kwd>sarcopenia</kwd><kwd>middle age</kwd><kwd>bioimpedancemetry</kwd><kwd>decreased muscle function</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>саркопения</kwd><kwd>средний возраст</kwd><kwd>биоимпедансометрия</kwd><kwd>снижение мышечной функции</kwd></kwd-group><funding-group><funding-statement xml:lang="en">The research was funded by the PHP grant "Early diagnosis of sarcopenia based on metabolic profile", 22-25-00632, 01.10.2022.</funding-statement><funding-statement xml:lang="ru">Данное исследование финансировалось грантом РНФ «Ранняя диагностика саркопении на основе метаболического профиля», 22-25-00632 от 10.01.2022.</funding-statement></funding-group></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Newman AB, Lee JS, Visser M, et al. 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