Terapevticheskii arkhivTerapevticheskii arkhivТерапевтический архив0040-36602309-5342LLC Obyedinennaya Redaktsiya10880110.26442/00403660.2022.05.201490ReviewsОбзорыReview ArticleEndogenous estrogen deficiency and the development of chronic musculoskeletal pain: A reviewДефицит эндогенных эстрогенов и развитие хронической скелетно-мышечной болиhttps://orcid.org/0000-0002-5290-156XPanevinTaras S.ПаневинТарас Сергеевич
Russian Federation

канд. мед. наук, науч. сотр. лаб. эволюции ревматоидного артрита, врач-эндокринолог

tarasel@list.ruhttps://orcid.org/0000-0002-9958-8988BobkovaAnastasia O.БобковаАнастасия Олеговна
Russian Federation

врач-ординатор

tarasel@list.ruhttps://orcid.org/0000-0002-1391-0711KarateevAndrey E.КаратеевАндрей Евгеньевич
Russian Federation

нач. отд. воспалительных заболеваний суставов

tarasel@list.ruhttps://orcid.org/0000-0002-4579-2836ZotkinEvgeniy G.ЗоткинЕвгений Германович
Russian Federation

д-р мед. наук, первый зам. дир.

tarasel@list.ruNasonova Research Institute of RheumatologyФГБНУ «Научно-исследовательский институт ревматологии им. В.А. Насоновой»170620229456836881706202217062022Copyright ©; 2022, Consilium MedicumCopyright ©; 2022, ООО "Консилиум Медикум"2022Consilium MedicumООО "Консилиум Медикум"https://creativecommons.org/licenses/by-nc-sa/4.0https://ter-arkhiv.ru/0040-3660/article/view/108801

Sexual dimorphism of chronic diseases is a phenomenon determined by differences in the hormonal status of men and women. In this regard, estrogens, which have a complex effect on the body, are of great interest. In particular, estrogens play an important role in the natural control of pain and inflammation. A decrease in estrogen levels associated with menopause or iatrogenic effects (hysterectomy, use of aromotase inhibitors), as well as mutations of genes responsible for the synthesis of structural components of membrane estrogen receptors (ESR1 and ESR2), can significantly reduce the positive effects of these hormones. Deficiency of estrogen can become one of the reasons for the development of serious pathological changes – in particular, the formation of chronic pain associated with the pathology of the musculoskeletal system.

Половой диморфизм хронических заболеваний – феномен, определяемый различиями гормонального статуса мужчин и женщин. В этом плане большой интерес представляют эстрогены, обладающие комплексным влиянием на организм. В частности, эстрогены играют важную роль в естественном контроле боли и воспаления. Снижение уровня эстрогенов, связанное с менопаузой или ятрогенным воздействием (гистерэктомия, применение ингибиторов ароматазы), а также мутации генов, отвечающих за синтез структурных компонентов мембранных рецепторов эстрогенов (ESR1 и ESR2), способны существенно снизить позитивные эффекты этих гормонов. Дефицит эстрогенов может стать одной из причин развития серьезных патологических изменений – в частности, формирования хронической боли, связанной с патологией скелетно-мышечной системы.

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