Terapevticheskii arkhivTerapevticheskii arkhivТерапевтический архив0040-36602309-5342LLC Obyedinennaya Redaktsiya10824010.26442/00403660.2022.04.201449ReviewsОбзорыReview ArticleSGLT2 inhibitors in acute decompensated heart failure, what do we know?Ингибиторы SGLT2 и острая декомпенсация сердечной недостаточности, что мы знаем?https://orcid.org/0000-0002-9260-9520LaptevaAnastasiya E.ЛаптеваАнастасия Евгеньевна
Russian Federation

аспирант отд. заболеваний миокарда и сердечной недостаточности

anastasiyalapteva95@gmail.comhttps://orcid.org/0000-0002-0920-7417NasonovaSvetlana N.НасоноваСветлана Николаевна
Russian Federation

канд. мед. наук, ст. науч. сотр. отд. заболеваний миокарда и сердечной недостаточности

anastasiyalapteva95@gmail.comhttps://orcid.org/0000-0002-4066-2661ZhirovIgor V.ЖировИгорь Витальевич
Russian Federation

д-р мед. наук, вед. науч. сотр. отд. заболеваний миокарда и сердечной недостаточности, проф. каф. кардиологии

anastasiyalapteva95@gmail.comhttps://orcid.org/0000-0001-9234-6129TereshchenkoSergey N.ТерещенкоСергей Николаевич
Russian Federation

д-р мед. наук, проф., рук. отд. заболеваний миокарда и сердечной недостаточности, зав. каф. кардиологии

anastasiyalapteva95@gmail.comChazov National Medical Research Center of CardiologyФГБУ «Национальный медицинский исследовательский центр кардиологии им. акад. Е.И. Чазова» Минздрава РоссииRussian Medical Academy of Continuous Professional EducationФГБОУ ДПО «Российская медицинская академия непрерывного профессионального образования» Минздрава России260520229445655712505202225052022Copyright ©; 2022, Consilium MedicumCopyright ©; 2022, ООО "Консилиум Медикум"2022Consilium MedicumООО "Консилиум Медикум"https://creativecommons.org/licenses/by-nc-sa/4.0https://ter-arkhiv.ru/0040-3660/article/view/108240

The current worldwide prevalence of heart failure is growing, while its combination with cardiovascular and other conditions determines a poor prognosis in these patients. Furthermore, acute decompensated heart failure is associated with a low survival rate mostly caused by target organ damage. The effects of early administration of SGLT2 inhibitors on renal function in patients with acute decompensated heart failure are being studied to determine the possibility of improving response to treatment, as well as partial or complete recovery of renal function. The goal of the review was to synthesize currently available evidence for the use of SGLT2 inhibitors in patients with acute decompensated heart failure. A systematic search for studies published from 2018 to 2021 and their analysis was carried out in the following databases: Web of Science, Scopus, PubMed/MEDLINE.

В настоящее время распространенность хронической сердечной недостаточности во всем мире постоянно увеличивается, а сочетание данного синдрома с другими заболеваниями кардиологического и некардиологического профиля определяет неблагоприятный прогноз у данных пациентов. В свою очередь, острая декомпенсация хронической сердечной недостаточности сопряжена с низкой выживаемостью больных во многом за счет поражения органов-мишеней. Изучение влияния раннего назначения ингибиторов натрий-глюкозного котранспортера 2-го типа (SGLT-2) на функцию почек у пациентов с острой декомпенсацией сердечной недостаточности, возможно, позволит улучшить результаты лечения и будет способствовать частичному или полному восстановлению почечной функции. Целью обзора являлись сбор и анализ имеющихся на сегодняшний день данных по применению ингибиторов SGLT2 у пациентов с острой декомпенсацией хронической сердечной недостаточности. Проведены систематический поиск и анализ результатов исследований, опубликованных с 2018 по 2021 г. в базах данных Web of Science, Scopus, PubMed/MEDLINE.

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