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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="other" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Terapevticheskii arkhiv</journal-id><journal-title-group><journal-title xml:lang="en">Terapevticheskii arkhiv</journal-title><trans-title-group xml:lang="ru"><trans-title>Терапевтический архив</trans-title></trans-title-group></journal-title-group><issn publication-format="print">0040-3660</issn><issn publication-format="electronic">2309-5342</issn><publisher><publisher-name xml:lang="en">LLC Obyedinennaya Redaktsiya</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">104872</article-id><article-id pub-id-type="doi">10.26442/00403660.2022.01.201327</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>History of medicine</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>История медицины</subject></subj-group><subj-group subj-group-type="article-type"><subject>Miscellaneous</subject></subj-group></article-categories><title-group><article-title xml:lang="en">Legionnaires disease: history of the discovery, the main stages of the study pathogen and infection</article-title><trans-title-group xml:lang="ru"><trans-title>Болезнь легионеров: история открытия, основные этапы исследования возбудителя и инфекции</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-4825-8951</contrib-id><name-alternatives><name xml:lang="en"><surname>Tartakovsky</surname><given-names>Igor S.</given-names></name><name xml:lang="ru"><surname>Тартаковский</surname><given-names>Игорь Семенович</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="ru"><p>д-р биол. наук, проф., зав. лаб. легионеллеза</p></bio><email>itartak@list.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-5748-178X</contrib-id><name-alternatives><name xml:lang="en"><surname>Maleev</surname><given-names>Viktor V.</given-names></name><name xml:lang="ru"><surname>Малеев</surname><given-names>Виктор Васильевич</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="ru"><p>акад. РАН, д-р мед. наук, проф., советник дир. по научной работе</p></bio><email>itartak@list.ru</email><xref ref-type="aff" rid="aff2"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Gamaleya National Research Center of Epidemiology and Microbiology</institution></aff><aff><institution xml:lang="ru">ФГБУ «Национальный исследовательский центр эпидемиологии и микробиологии им. Н.Ф. Гамалеи» Минздрава России</institution></aff></aff-alternatives><aff-alternatives id="aff2"><aff><institution xml:lang="en">Central Research Institute of Epidemiology</institution></aff><aff><institution xml:lang="ru">ФБУН «Центральный научно-исследовательский институт эпидемиологии» Роспотребнадзора</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2022-01-15" publication-format="electronic"><day>15</day><month>01</month><year>2022</year></pub-date><volume>94</volume><issue>1</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><fpage>145</fpage><lpage>148</lpage><history><date date-type="received" iso-8601-date="2022-03-14"><day>14</day><month>03</month><year>2022</year></date><date date-type="accepted" iso-8601-date="2022-03-14"><day>14</day><month>03</month><year>2022</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2022, Consilium Medicum</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2022, ООО "Консилиум Медикум"</copyright-statement><copyright-year>2022</copyright-year><copyright-holder xml:lang="en">Consilium Medicum</copyright-holder><copyright-holder xml:lang="ru">ООО "Консилиум Медикум"</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://creativecommons.org/licenses/by-nc-sa/4.0</ali:license_ref></license></permissions><self-uri xlink:href="https://ter-arkhiv.ru/0040-3660/article/view/104872">https://ter-arkhiv.ru/0040-3660/article/view/104872</self-uri><abstract xml:lang="en"><p>The article discusses main directions and stages of the 45 years of Legionnaires disease study. Analysis of epidemiology and laboratory diagnostics of infection show as unknown until 1976 microorganism occupied a notable niche in the etiology of severe pneumonia. Control and monitoring of potential dangerous water systems, generating water aerosol containing Legionella in high concentration, plays a major role in the prevention of Legionnaires disease.</p></abstract><trans-abstract xml:lang="ru"><p>В статье рассматриваются основные направления и этапы 45-летнего изучения болезни легионеров. Анализ эпидемиологии и лабораторной диагностики инфекции показывает, как неизвестный до 1976 г. микроорганизм занял заметное место в этиологии тяжелых пневмоний. Отмечено важное значение профилактики легионеллезной инфекции на основе контроля и мониторинга потенциально опасных для человека водных систем, генерирующих водный аэрозоль, содержащий легионеллы в высокой концентрации.</p></trans-abstract><kwd-group xml:lang="en"><kwd>Legionnaires disease</kwd><kwd>pneumonia</kwd><kwd>laboratory diagnostic</kwd><kwd>prevention</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>болезнь легионеров</kwd><kwd>пневмония</kwd><kwd>лабораторная диагностика</kwd><kwd>профилактика</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>McDade JE, Shepard CC, Fraser DM. Legionnaires disease. Isolation of bacterium and demonstration of its role in other respiratory disease. N Engl J Med. 1977;297:1197-203.</mixed-citation></ref><ref id="B2"><label>2.</label><mixed-citation>Weaver RE. Cultural and staining characteristics. In: Legionnaires disease, the bacterium and methodology. Ed. 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