Трехмерное моделирование абляции опухоли печени с использованием электродов с несколькими зубцами

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В работе представлены результаты трехмерного моделирования с использованием метода конечных элементов селективного уничтожения опухолей, расположенных в области раздвоенных кровеносных сосудов. Методология подразумевает подготовку троакара, оснащенного особой конфигурацией многозубчатых электродов, который функционирует как источник тепла для эффективного устранения злокачественных клеток при сохранении целостности окружающей здоровой ткани. Получены профили электрического потенциала, температуры и доли повреждений. Для количественной оценки степени повреждения ткани изучены доли некротической ткани в различных местах. Результаты убедительно демонстрируют, что клетки эффективно уничтожаются в направлении электродов, во всех других направлениях клетки остаются неповрежденными. Установлено, что увеличение входного напряжения от 22 до 27 В приводит к соответствующему повышению температуры внутри ткани. Анализ влияния скорости перфузии крови в диапазоне от 6.4×10–7 до 6.4×10–2 1/с на температуру показал, что более низкая скорость перфузии приводит к более высоким значениям температуры внутри печени. Предлагаемая модель имеет значительные перспективы как инструмент для онкологов, который можно использовать при разработке эффективных процедур термической абляции опухолей при минимальном сопутствующем ущербе здоровых тканей.

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Sobre autores

E. Poorreza

Sahand University of Technology

Autor responsável pela correspondência
Email: elnaz.poorreza@gmail.com

Faculty of Electrical Engineering

Irã, Tabriz

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2. Fig. 1. Schematic representation of a bifurcated blood vessel and a multi-prong probe (a) and a probe model (b).

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3. Fig. 2. Calculation grid.

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4. Fig. 3. Distribution of electric potential in the XZ plane inside liver tissue when exposed for 10 min to an electrode with a different number of prongs: (a) – one prong, (b) – two, (c) – three, (d) – six.

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5. Fig. 4. Distribution of temperature in the XZ plane inside liver tissue near an electrode with one prong (a), two (b), three (c), six (d).

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6. Fig. 5. Isothermal surfaces T = 50°C in the XZ plane inside liver tissue when using an electrode with a different number of prongs: (a) – one prong, (b) – two, (c) – three, (d) – six.

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7. Fig. 6. Volume distributions of the proportion of damage in the liver tissue for an electrode with one tooth (a), two (b), three (c), six (d).

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8. Fig. 7. Increase in the proportion of liver tissue damage over time when using an electrode with one tooth (a), two (b), three (c), six (d); A–D correspond to points in Fig. 5a.

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9. Fig. 8. Dependences of temperature at the critical point (–16.6, 0, 60) near an electrode with one tooth (a), two (b), three (c), six (d).

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10. Fig. 9. Temperature values at the electrode surface depending on voltage for different numbers of teeth: 1 – one tooth, 2 – two, 3 – four, 4 – six.

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11. Fig. 10. Temperature values at the electrode surface depending on the blood perfusion rate when using an electrode with different numbers of teeth: 1 – one tooth, 2 – two, 3 – four, 4 – six.

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12. Fig. 11. Comparative view of isothermal surfaces (T = 50°C) in liver tissue at a blood perfusion rate of 6.4×10–7 1/s (a), (c), (d), (g) and 6.4×10–2 1/s (b), (d), (e), (h) and different numbers of electrode teeth: (a), (b) – one tooth; (c), (d) – two; (d), (f) – four; (g), (h) – six.

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13. Fig. 12. Comparative view of damage fraction fields at a blood perfusion rate of 6.4×10–7 1/s (a), (c), (d), (g) and 6.4×10–2 1/s (b), (d), (e), (h) and different numbers of electrode teeth: (a), (b) – one tooth; (c), (d) – two; (e), (f) – four; (f), (z) – six.

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