Probabilistic Assessment of a Pentapeptide Composition Influence on Its Stability

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Resumo

The influence of the arrangement of amino acid residues in a pentapeptide on its stability is being studied. A forecast of pentapeptide stability is made using the gradient boosting method, which allows one to evaluate the influence of each feature on the stability of the pentapeptide. Combinations of amino acid arrangements in the pentapeptide have been identified that make a significant contribution to its stability. It has been shown that the use
of such combinations reduces the amount of data required to obtain a reliable prediction of pentapeptide stability.

Sobre autores

A. Mikhal'skiy

Trapeznikov Institute of Control Sciences, Russian Academy of Sciences

Email: ipuran@yandex.ru
Moscow, Russia

Zh. Novosel'tseva

Trapeznikov Institute of Control Sciences, Russian Academy of Sciences

Email: novoselc.janna@yandex.ru
Moscow, Russia

A. Anashkina

Engelgardt Institute of Molecular Biology, Russian Academy of Sciences

Email: a_anastasya@inbox.ru
Moscow, Russia

A. Nekrasov

Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences

Autor responsável pela correspondência
Email: a_nnekrasov@mail.ru
Moscow, Russia

Bibliografia

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  8. Mikhalskii A.I., Petrov I.V., Tsurko V.V., Anashkina A.A. et al. Application of mutual information estimation for prediction the structural stability of pentapeptides // Rus. J. Numer. Anal. Math. Model. 2020. V. 35. No. 5. P. 263-271.

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