oesophagus according to Rome IV criteria (2016) are presented. The data of the private investigation are demonstrated according to which irritated oesophagus was observed in 26.2% of healthy persons and in 24.2% of GERD patients with endoscopic or pH-metric symptoms of the disease. Implication of oesophagus clearance disorder in GERD pathogenesis has been pointed out. An overview of the current literature data about effectiveness of surgical treatment in patients with different GERD phenotypes and also assessment of clinical effectiveness of long-term treatment with PPI are given. Advantages of anti-secretory drug of the last generation rabeprazole in different patient groups and possibilities of its use in all GERD phenotypes have been discussed.
Keywords: course of gastroesophageal reflux disease, prognosis of treatment effectiveness, hypersensitive, irritable oesophagus, functional heartburn, pH-impedance monitoring, proton pump inhibitors, rabeprazole
About the AuthorO.A. Sablin 1 , T.A. Ilchishina 2
1 А.М. Nikiforov Russian Center of Emergency and Radiation Medicine, Ministry of Russian Federation for Civil Defense, Emergencies and Elimination of Consequences of Natural Disasters, Saint-Petersburg, Russia
2 SM-clinic, Saint-Petersburg, Russia